A randomized trial of controlled-release oxycodone during inpatient rehabilitation following unilateral total knee arthroplasty

The Journal of Bone and Joint Surgery. American Volume
A ChevilleE Narcessian

Abstract

Reliance on "as-needed" analgesia following total knee arthroplasty may lead to inadequate control of pain and delayed recovery of function. Preemptive use of controlled-release opioids may improve pain control, accelerate recovery, and reduce the need for inpatient rehabilitative services. This study was designed to determine whether controlled-release opioids enhance post-arthroplasty pain control and facilitate functional recovery during rehabilitation. Fifty-nine patients admitted for inpatient rehabilitation following unilateral total knee arthroplasty were randomized to receive OxyContin (controlled-release oxycodone) (twenty-nine patients) or a placebo (thirty patients) every twelve hours. Both groups could receive on-request, immediate-release oxycodone (5 mg every four hours). The dose of study medication was increased on the basis of the frequency of requests for immediate-release oxycodone. Measures of interest included pain ratings as determined with a visual-analog scale, changes in the range of motion of the knee and quadriceps strength, and improvements in selected Functional Independence Measure scores during the first eight physical therapy sessions. The duration of the hospital stay for rehabilitation also was...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1982·Addictive Behaviors·H A Skinner
Jul 1, 1995·American Journal of Physical Medicine & Rehabilitation·M C MuninH E Rubash
Feb 1, 1997·Disability and Rehabilitation·N M FisherD R Pendergast
Apr 1, 1997·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·C K KwohM C Munin

❮ Previous
Next ❯

Citations

Oct 5, 2006·Current Opinion in Anaesthesiology·Joel Katz, Colin J L McCartney
Jan 28, 2020·The Journal of Bone and Joint Surgery. American Volume·Spencer SummersVictor Hugo Hernandez
May 29, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Rakesh Rao, Nirmala S Desai
Jan 7, 2004·The American Journal of Nursing·Chris Pasero, Margo McCaffery
May 24, 2005·Current Pain and Headache Reports·Nathaniel Katz, Christine Benoit
Jan 19, 2006·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·Diane Meier
Jun 28, 2007·Journal for Specialists in Pediatric Nursing : JSPN·Michelle L CzarneckiSteven J Weisman
May 26, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Ordóñez GallegoE Espinosa Arranz
Apr 9, 2010·Journal of Spinal Disorders & Techniques·Sharad RajpalDaniel K Resnick
Jan 31, 2002·Drugs·Sanford H Roth
Dec 24, 2002·Drugs & Aging·Mahmood Ahmad, Charles Roger Goucke
Dec 5, 2008·Journal of the American Geriatrics Society·R Sean MorrisonAlbert L Siu
Apr 22, 2008·The Cochrane Database of Systematic Reviews·F KhanL Turner-Stokes
Jan 30, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Huichao FuXianlong Zhang
Mar 6, 2015·Revista do Colégio Brasileiro de Cirurgiões·Ismar Lima CavalcantiLuis Antonio Vane
Dec 16, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Declan Walsh
Mar 21, 2007·American Journal of Physical Medicine & Rehabilitation·Timothy R Dillingham
May 8, 2009·Current Medical Research and Opinion·Margaret RothmanDavid J Hewitt
Apr 13, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthew RobertsGeoffrey Mitchell
Sep 4, 2015·Geriatric Orthopaedic Surgery & Rehabilitation·Alexander J BollingerTerrence J Endres
Aug 2, 2017·Clinical Orthopaedics and Related Research·Seth S Leopold, Lee Beadling
Sep 16, 2010·Orthopedics·Michael P Nett
May 21, 2008·Der Schmerz·E M Pogatzki-Zahn, P K Zahn
Jun 7, 2003·Pain·Sean R MorrisonAlbert L Siu
Nov 28, 2007·Current Medical Research and Opinion·Julia RileyLars Arendt-Nielsen
Oct 28, 2016·Journal of the American Geriatrics Society·R Sean MorrisonKnox H Todd
Sep 6, 2020·The Journal of Bone and Joint Surgery. American Volume·Christopher S SmithDaniel B Whelan
Oct 22, 2020·The Journal of Bone and Joint Surgery. American Volume·Christopher S SmithDaniel B Whelan
Jun 10, 2011·The Journal of Bone and Joint Surgery. American Volume·Javad ParviziKishor Gandhi
Feb 9, 2021·Arthroplasty Today·Keenan AtwoodAdam E Klein
Jul 18, 2015·Orthopedics·Mohamad J HalawiMichael P Bolognesi
Jun 5, 2003·Clinics in Podiatric Medicine and Surgery·Trevor A DavySue Lynch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.