A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis.

Journal of Thrombosis and Haemostasis : JTH
Suman RathbunT L Whitsett

Abstract

Superficial thrombophlebitis can produce pain and result in a deep vein thrombosis (DVT) if not treated. Conservative therapies including prescription of non-steroidal anti-inflammatory drugs (NSAID) and heat have been standard care. Recently, studies have been published reporting efficacy and safety of low-molecular-weight heparin for the treatment of superficial thrombophlebitis. However, there are few comparative trials to conservative therapy. We studied the effectiveness and safety of treatment with dalteparin compared with ibuprofen in patients with confirmed superficial thrombophlebitis. Consecutive patients were randomized to receive daily dalteparin vs. ibuprofen three times daily for up to 14 days. The primary outcome measure was the incidence of extension of thrombus or new symptomatic venous thromboembolism during the 14-day and 3-month follow-up period. The secondary outcome was a reduction in pain. The outcome measure of safety was the incidence of major and minor bleeding. Of 302 consecutive patients screened, 72 were enrolled. Four patients receiving ibuprofen compared with no patients receiving dalteparin had thrombus extension at 14 days (P = 0.05), however, there was no difference in thrombus extension at 3 m...Continue Reading

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References

May 15, 1991·Postgraduate Medicine·H L MessmoreW H Wehrmacher
Nov 1, 1996·Journal of Vascular Surgery·D L ChengelisT J Ranval
Jan 13, 1997·Archives of Internal Medicine·P PrandoniA Girolami
Mar 24, 1998·Journal of Vascular Surgery·R M BlumenbergJ Brennan
Nov 11, 1998·Journal of Vascular Surgery·L J DowningT W Wakefield
Nov 16, 2001·Journal of the American College of Surgeons·V SullivanT W Wakefield
Jun 11, 2005·Journal of Thrombosis and Haemostasis : JTH·P PrandoniUNKNOWN Vesalio Investigators Group
Sep 24, 2010·The New England Journal of Medicine·Hervé DecoususUNKNOWN CALISTO Study Group

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Citations

Sep 11, 2012·Best Practice & Research. Clinical Haematology·Hervé DecoususAlain Leizorovicz
Dec 19, 2014·British Journal of Haematology·Gemma ScottRaza Alikhan
Aug 15, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K BoehlerS Tzaneva
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·H DécoususP Frappé
Jun 14, 2015·Current Problems in Surgery·Dawn M ColemanPeter K Henke
Jun 13, 2015·Advances in Pharmacological Sciences·Sarah MousaviMaryam Motamedi
Sep 7, 2013·Blood·Barbara A Konkle
Jun 21, 2016·Indian Journal of Dermatology, Venereology and Leprology·Keshavmurthy A AdyaAparna Palit
Apr 8, 2016·Phlebology·Christos KarathanosAthanasios D Giannoukas
Mar 27, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Andrew NicolaidesUNKNOWN International Union of Angiology and Union Internationale du Phlebologie
Feb 27, 2018·The Cochrane Database of Systematic Reviews·Marcello Di NisioSaskia Middeldorp
Nov 21, 2015·The Cochrane Database of Systematic Reviews·Marcello Di NisioAnne Ws Rutjes
May 2, 2013·The Cochrane Database of Systematic Reviews·Marcello Di NisioSaskia Middeldorp
Aug 21, 2020·Thrombosis and Haemostasis·Danielle M H BeurskensGerry A F Nicolaes

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