A randomized trial of minidose warfarin for the prevention of late malfunction in tunneled, cuffed hemodialysis catheters

Kidney International
M H MokrzyckiS O Rosenberg

Abstract

Minidose warfarin (1 mg/day) has been associated with a 74% reduction in the thrombosis rate of central venous catheters used in oncology patients. To determine the efficacy of minidose warfarin on late malfunction caused by thrombosis or fibrin sheath formation in tunneled, cuffed catheters (TCC) used for hemodialysis (HD), we performed a randomized, placebo-controlled trial. One hundred five chronic HD patients with TCCs were initially randomized. Of these, 85 (warfarin 41 and placebo 44) completed the first two weeks of the protocol and were followed for the first year of TCC life or until TCC removal. Sixteen TCCs failed with late TCC malfunction, eight in each group. In a multivariate analysis, there was no significant effect of warfarin on thrombosis-free TCC survival or time to the first urokinase (UK) instillation for incipient thrombosis. The presence of a low hemoglobin (Hgb; <10.5 g/dL) or a low international normalized ratio (INR; <1.00) was significantly associated with a higher risk of late TCC malfunction (RR 5.2 and 4.0, respectively), a higher risk of incipient TCC thrombosis requiring UK (RR 2.0 and 2.8, respectively), and higher rates of UK dosing. Diabetics had a 3.6-fold higher risk of late TCC malfunction ...Continue Reading

References

Sep 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A H MossD E McDowell
Feb 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S J SchwabD L Stickel
Jan 1, 1996·American Journal of Nephrology·D W Butterly, S J Schwab
Sep 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P V SuhockiS J Schwab
Aug 26, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jan 14, 2000·JAMA : the Journal of the American Medical Association·J B MeigsP W Wilson
Feb 17, 2000·Journal of the American College of Cardiology·M ShechterS Kaul

❮ Previous
Next ❯

Citations

Nov 17, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rudolph P ValentiniDeepa H Chand
Jul 18, 2009·Internal and Emergency Medicine·Guido Finazzi, Giulio Mingardi
Jun 1, 2004·Seminars in Interventional Radiology·Mary S Hammes
Jan 28, 2011·The New England Journal of Medicine·Brenda R HemmelgarnUNKNOWN Prevention of Dialysis Catheter Lumen Occlusion with rt-PA versus Heparin Study Group
Jun 13, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael Allon
Oct 31, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amanda Y WangMeg J Jardine
Feb 7, 2008·Seminars in Dialysis·Lisa Willms, Lavern M Vercaigne
Nov 13, 2008·Seminars in Dialysis·Micah R Chan
Sep 12, 2009·Seminars in Dialysis·Rachel M Holden, Catherine M Clase
Dec 20, 2011·Seminars in Dialysis·Vandana Dua Niyyar
Jun 24, 2004·Artificial Organs·Simon Desmeules, Bernard Canaud
May 13, 2011·Nephron. Clinical Practice·Richard Fluck, Mick Kumwenda
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Kevin E ChanRaymond M Hakim
Nov 16, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Rachel M HoldenAndrew G Day
Apr 16, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Trevor J WilkiesonCatherine M Clase
Apr 21, 2012·International Journal of Nephrology·Timmy LeeMichele Mokrzycki
Oct 1, 2010·Kidney International·Michele H Mokrzycki, Charmaine E Lok
Aug 30, 2011·Blood Reviews·Sue Pavord, Bethan Myers
Dec 17, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fabio PaglialongaAlberto Edefonti
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meghan J ElliottRachel M Holden
Aug 19, 2007·Seminars in Oncology Nursing·Dawn Camp-Sorrell
Jun 25, 2005·Journal of Thrombosis and Haemostasis : JTH·C J RoodenM V Huisman
Feb 20, 2013·Journal of Clinical Apheresis·Ladan Golestaneh, Michele H Mokrzycki
Mar 31, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kazutaka KukitaUNKNOWN Vascular Access Construction and Repair for Chronic Hemodialysis Guideline Working Group, Japanese Society for Dialysis Ther
Jul 5, 2005·Thrombosis Research·Avtar S SohalDarin Treleaven
Mar 19, 2011·Journal of the American College of Cardiology·Ricarda MarinighGregory Y H Lip
Jun 19, 2016·Thrombosis Research·Christi M TerryAlfred K Cheung
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Murray Bern
Mar 10, 2017·Journal of Evidence-based Medicine·Georgios Vlachopanos, Farid Girgis Ghalli
Nov 23, 2012·The Journal of Vascular Access·William G HerringtonEmma C Vaux
Sep 30, 2014·The Journal of Vascular Access·Kevin ChaplaMicah R Chan
Mar 10, 2016·The Journal of Vascular Access·Maurizio GallieniMaurizio Cariati
Nov 7, 2017·The Cochrane Database of Systematic Reviews·Alice L KennardGirish S Talaulikar
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michael ZellwegerFrançois Madore
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Michael Allon
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Puneet SoodEric P Cohen
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·William M Bennett
Jul 5, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Vandana Dua Niyyar, Micah R Chan
Feb 2, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michele H MokrzyckiStuart O Rosenberg
Aug 25, 2020·The Journal of Vascular Access·Giovanna PassaroAntonio La Greca
Dec 4, 2016·Hematology·Michele P Lambert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
James S KaufmanVeterans Affairs Cooperative Study Group on Hemodialysis Access Graft Thrombosis
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Michael ZellwegerFrançois Madore
© 2021 Meta ULC. All rights reserved