A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants

Pediatric Pulmonology
Pedro FloresAna S Neto

Abstract

Acute bronchiolitis is a common disorder of infants that often results in hospitalization. Apart from supportive care, no therapy has been shown to influence the course of the disease, except for a possible effect of nebulized hypertonic saline (HS). To determine whether this does have beneficial effects on length of stay in hospital or on severity scores, we undertook a double-blind, randomized, controlled trial in a pediatric department of a Portuguese hospital. Previously healthy infants, younger than 12 months, hospitalized with mild-to-moderate acute viral bronchiolitis were randomized to receive either nebulized 3% (hypertonic, HS) or 0.9% (normal, NS) saline during their entire hospital stay. Primary endpoints were: length of hospital stay and severity scores on each day of hospitalization. Need for supplemental oxygen, further add-on medications and adverse effects were also analyzed. Sixty-eight patients completed the study (HS: 33; NS: 35). The median length of hospital stay did not differ between groups: HS: 5.6 ± 2.3 days; NS: 5.4 ± 2.1 days (P = 0.747). We found no difference between groups in severity scores from day 1 to day 4. There were no differences in need for supplemental oxygen or add-on medications. Patie...Continue Reading

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Citations

Apr 29, 2016·Pediatric Pulmonology·Richard AutenTerry L Noah
May 14, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Christopher L Carroll The Northeast Pediatric Critical Care Research Consortium
Aug 24, 2016·Lancet·Todd A FlorinJoseph J Zorc
Apr 26, 2017·Pediatric Pulmonology·Richard AutenTerry L Noah
Feb 25, 2018·World Journal of Pediatrics : WJP·Paula HeikkiläMatti Korppi
Sep 7, 2019·Archives of Disease in Childhood·Raphaelle Jaquet-PilloudJean-Yves Pauchard
Dec 22, 2017·The Cochrane Database of Systematic Reviews·Linjie ZhangTerry P Klassen
Aug 7, 2019·Experimental and Therapeutic Medicine·Zhi-Yong WangXue-Qin Fu
Dec 22, 2017·Pediatric Pulmonology·Paula HeikkiläMatti Korppi
Jan 13, 2018·Pediatric Pulmonology·Yoshihiko MorikawaUNKNOWN Tokyo Pediatric Clinical Research Network
Dec 22, 2017·Pediatric Pulmonology·Thanakorn KanjanapradapNuanchan Prapphal
Aug 18, 2018·Pediatrics·Wade HarrisonShawn L Ralston

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