A randomized trial of the effects of flaxseed to manage constipation, weight, glycemia, and lipids in constipated patients with type 2 diabetes

Nutrition & Metabolism
Noureddin Soltanian, Mohsen Janghorbani

Abstract

To compare the effects of baked flaxseed versus those who received a placebo on constipation symptom scores, weight, glycemic and lipid control in constipated patients with type 2 diabetes (T2D). In a single-blinded, randomized controlled trial, 53 constipated patients with T2D with body mass index (BMI) 20.5-48.9 kg/m2 received either 10 g of flaxseed pre-mixed in cookies twice per day or placebo cookies for 12 weeks. The constipation symptom scores, BMI, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and lipid profile were determined at the beginning and end of 4, 8, and 12-week period. Constipation was evaluated with a stool diary (ROME III). After the 12-week intervention, constipation symptom scores (2.46), weight (- 3.8 kg), BMI (- 1.5 kg/m2), FPG (- 26.7 mg/dl), cholesterol (- 37.3 mg/dl), triglycerides (- 10.4 mg/dl), LDLC (- 21.0 mg/dl), HDLC (4.7 mg/dl), cholesterol/ HDLC ratio (- 1.4 mg/dl) significantly decreased from baseline in the flaxseed group (all P-values < 0.05). The differences of absolute change of constipation symptom scores (2.46 vs. 0.41), weight (- 3.8 vs. 0.0 kg), BMI (- 1.5 vs.-0.1 kg/m2), FPG (- 26.7 vs.-1.9 mg/dl), >HbA1c (- 0.8 vs. 1.0%), cholesterol (- 37.3 vs. -10.4 mg/dl), LDLC ...Continue Reading

References

Oct 12, 2000·Archives of Internal Medicine·D MalekiL J Melton
Jul 4, 2001·The Journal of Laboratory and Clinical Medicine·K Prasad
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Apr 2, 2002·The American Journal of Gastroenterology·Peter BytzerMichael Horowitz
Dec 29, 2005·Journal of Medicinal Food·Wendy J DahlSusan J Whiting
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·J F Johanson, J Kralstein
Feb 28, 2008·Physiology & Behavior·Elke Theuwissen, Ronald P Mensink
Aug 1, 2008·Plant Physiology·Radnaa NaranNicholas C Carpita
Jun 12, 2009·The American Journal of Clinical Nutrition·An PanXu Lin
Jun 24, 2009·International Journal of Food Sciences and Nutrition·Goutam ThakurDérick Rousseau
Jun 30, 2012·The Journal of Clinical Endocrinology and Metabolism·M Denise RobertsonA Margot Umpleby
Sep 23, 2014·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Christiane Ishikawa RamosLilian Cuppari
Apr 19, 2015·Journal of Ethnopharmacology·Amber Hanif Palla, Anwarul-Hassan Gilani
Aug 25, 2015·The Lancet. Diabetes & Endocrinology
Jul 20, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Abigail Maisey
Jun 22, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohammadi-SartangJ O Totosy de Zepetnek

❮ Previous
Next ❯

Citations

May 28, 2019·Nutrients·Mihir ParikhGrant N Pierce
Jun 28, 2019·Therapeutic Advances in Gastroenterology·Theresa MeldgaardAsbjørn Mohr Drewes
Jun 26, 2021·World Journal of Diabetes·Marcio José Concepción ZavaletaLuis Alberto Concepción Urteaga

❮ Previous
Next ❯

Methods Mentioned

BETA
ion-exchange chromatography

Software Mentioned

SPSS
Nutritionist IV
Nutritionist
Nutritional Database Manager

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.