PMID: 8948338Oct 1, 1996Paper

A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844

International Journal of Radiation Oncology, Biology, Physics
A B KarimMartine Van Glabbeke

Abstract

Cerebral low-grade gliomas (LGG) in adults are mostly composed of astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. There is at present no consensus in the policy of treatment of these tumors. We sought to determine the efficacy of radiotherapy and the presence of a dose-response relationship for these tumors in two multicentric randomized trials conducted by the European Organization for Research and Treatment of Cancer (EORTC). The dose-response study is the subject of this article. For the dose-response trial, 379 adult patients with cerebral LGGs were randomized centrally at the EORTC Data Center to receive irradiation postoperatively (or postbiopsy) with either 45 Gy in 5 weeks or 59.4 Gy in 6.6 weeks with quality-controlled radiation therapy. All known parameters with possible influences on prognosis were prospectively recorded. Conventional treatment techniques were recommended. With 343 (91%) eligible and evaluable patients followed up for at least 50 months with a median of 74 months, there is no significant difference in terms of survival (58% for the low-dose arm and 59% for the high-dose arm) or the progression free survival (47% and 50%) between the two arms of the trial. However, this prospective tria...Continue Reading

References

Jul 1, 1977·International Journal of Radiation Oncology, Biology, Physics·J T Fazekas
Jun 1, 1989·Journal of Neurosurgery·E G ShawH Okazaki
Mar 1, 1986·Journal of Neurosurgery·P J KellyF Earnest
Oct 15, 1994·International Journal of Radiation Oncology, Biology, Physics·A B Karim
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·B RajanM Brada

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Citations

Apr 6, 2001·Seminars in Surgical Oncology·K K HerfarthJ Debus
Feb 24, 2001·Brain Tumor Pathology·J M Piepmeier
Jun 5, 2008·Neuroradiology·Elke HattingenUlrich Pilatus
Aug 22, 2007·European Journal of Nuclear Medicine and Molecular Imaging·A SmitsD Ribom
Jan 13, 2005·Journal of Neurology·Jan H MehrkensChristoph B Ostertag
Jun 12, 2002·Current Treatment Options in Oncology·V W Stieber
Jun 12, 2002·Current Treatment Options in Oncology·K J CohenJ Glod
Oct 31, 2003·Current Treatment Options in Oncology·Thomas L EllisRebekah C Austin
Apr 22, 2009·Current Treatment Options in Oncology·Jimmy Ruiz, Glenn J Lesser
Apr 15, 2003·Current Neurology and Neuroscience Reports·Marc SansonKhe Hoang-Xuan
Apr 23, 2004·Current Neurology and Neuroscience Reports·Lynn S Ashby, William R Shapiro
Mar 29, 2006·Current Oncology Reports·Paul D Brown
Apr 29, 2010·Current Oncology Reports·Patrick Y WenEudocia Quant
May 26, 2004·Current Treatment Options in Neurology·Edward J. Dropcho
Jun 22, 2005·Current Treatment Options in Neurology·Warren P Mason
Jun 27, 2008·Current Treatment Options in Neurology·Sandeep MittalGeoffrey R Barger
Jul 17, 2012·Current Treatment Options in Neurology·Shaheryar Hafeez, Robert Cavaliere
Jan 19, 2013·Paediatric Drugs·Trent R HummelDavid Franz
May 22, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·A SahgalL Paszat
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Stephanie E CombsJuergen Debus
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nader Sanai, Mitchel S Berger
Jan 31, 2004·Surgical Neurology·Walter A Hall
Sep 16, 2003·Journal of the Neurological Sciences·Simon S LoKathryn E Dusenbery
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·J NuutinenH Minn
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·M M FitzekF S Pardo
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·B J FisherL Stitt
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Andrea PirzkallPenny K Sneed
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Robert C KrempienFrederik Wenz
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·M P SunyachD Frappaz
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Branislav JeremicMiroslav Stojanovic
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Christian PlathowJürgen Debus
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·C R FreemanJ Montes
Nov 26, 1999·International Journal of Radiation Oncology, Biology, Physics·G BaumanJ G Cairncross
Mar 21, 1998·Seminars in Oncology Nursing·R A Strohl
Dec 24, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·G E GerrardD Levy
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A A BrandesC Vecht
Feb 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V BudachJ C Horiot
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Efficace, A Bottomley
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T B JohannesenK Lote
Feb 19, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M KiebertA B Karim
Dec 5, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·David G Walker, Andrew H Kaye
Mar 3, 1998·Journal of the American College of Surgeons·I A Awad
Jul 10, 2003·Lancet Neurology·Peter H WesselsAlbert Twijnstra
Nov 6, 2007·Nature Clinical Practice. Neurology·Nader PouratianDavid Schiff

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