A randomly-controlled study on the cardiac function at the early stage of return to the plains after short-term exposure to high altitude.

PloS One
Qiquan ZhouYong Fan

Abstract

High altitude acclimatization and adaptation mechanisms have been well clarified, however, high altitude de-adaptation mechanism remains unclear. In this study, we conducted a controlled study on cardiac functions in 96 healthy young male who rapidly entered the high altitude (3700 m) and returned to the plains (1500 m) after 50 days. Ninety eight healthy male who remained at low altitude were recruited as control group. The mean pulmonary arterial pressure (mPAP), left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), cardiac function index (Tei index) were tested. Levels of serum creatine kinase isoform MB (CK-MB), lactate dehydrogenase isoenzyme-1 (LDH-1), endothelin-1 (ET-1), nitrogen oxide (NO), serum hypoxia-inducible factor-1α (HIF-1α), 8-iso-prostaglandin F(2α) (8-iso PGF(2α)), superoxide dismutase (SOD) and malonaldehyde (MDA) were measured at an altitude of 3700 m and 1500 m respectively. The results showed that after short-term exposure to high altitude mPAP and Tei index increased significantly, while LVEF and LVFS decreased significantly. These changes were positively correlated with altitude. On the 15(th) day after the subjects returned to low altitude, mPAP, LVEF and LVFS levels ...Continue Reading

References

Jan 1, 1975·Scandinavian Journal of Thoracic and Cardiovascular Surgery·M B Sorensen
Jun 1, 1991·Journal of Applied Physiology·D C McKenzieW Ammann
Feb 1, 1974·Journal of Applied Physiology·J A VogelJ C Cruz
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·G SavoureyJ Bittel
Nov 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·C TeiS B Seward
Jun 30, 1998·FEBS Letters·S Basu
Apr 17, 2002·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Byeong-Han LeeBrendan M Corcoran
May 29, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qilin AoDixun Wang
Jan 25, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jian WangJ T Sylvester
Jan 29, 2005·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Wayne A BardwellPaul J Mills
Dec 26, 2006·Blood Cells, Molecules & Diseases·Angela RissoGuglielmo Antonutto
Feb 13, 2007·Travel Medicine and Infectious Disease·Charles Clarke
Jul 14, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Xiuzhang LuShuping Ge
Mar 5, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sarah ChuaJudy Hung
Jul 2, 2010·Current Opinion in Cardiology·Andre La GercheJens-Uwe Voigt
Apr 14, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Zi-fu ShiHan Luo
May 1, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Lee Fong LingThomas H Marwick
Dec 1, 2005·Forensic Science, Medicine, and Pathology·Roger W Byard, Michael Tsokos

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Citations

Mar 24, 2016·High Altitude Medicine & Biology·Christopher John BoosDavid Richard Woods
May 18, 2016·Mediators of Inflammation·Binfeng HeXiaolan Guo
Mar 8, 2017·High Altitude Medicine & Biology·Jiaxing ZhangMing Fan
Jun 18, 2021·Vascular Health and Risk Management·Robert T MalletMartin Burtscher

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Methods Mentioned

BETA
MDA
ELISA

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