A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients

Critical Care Medicine
M H KollefWilliam Shannon

Abstract

To determine whether the results of a rapid, semiquantitative assay for the detection of circulating D-dimer in whole blood (SRDD assay) are associated with the occurrence of clinical outcomes among critically ill patients. Prospective, blinded, single-center study. Medical intensive care unit (ICU) of Barnes-Jewish Hospital, St. Louis, MO, a university-affiliated teaching hospital. Three hundred twenty-three adult patients admitted to a medical ICU. Collection of blood samples within 24 hrs of ICU admission. The main outcome measures evaluated included vascular thrombosis, hospital mortality, and the development of multiorgan dysfunction. Fifty (15.5%) patients were found to have increased concentrations of D-dimer as detected by the SRDD assay within 24 hrs of ICU admission. The concentrations of plasma D-dimer simultaneously measured by an enzyme immunoassay based on the same antibody were significantly greater among patients with a positive SRDD assay compared with patients with a negative SRDD assay (1214+/-483 vs. 405+/-407 ng/mL; p< .001). The hospital mortality rate was significantly greater among SRDD-positive patients compared with SRDD-negative patients (32.0% vs. 15.0%; p=.004). SRDD-positive patients also had signi...Continue Reading

References

Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Sep 15, 1983·Thrombosis Research·D B RylattA J Webber
Jul 26, 1995·JAMA : the Journal of the American Medical Association·D R HirschS Z Goldhaber
May 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B BrennerD Rylatt
May 1, 1996·World Journal of Surgery·G Schlag, H Redl
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·W M FeinbergJ Kittelson

❮ Previous
Next ❯

Citations

Jan 15, 2008·Intensive Care Medicine·Athina LavrentievaMaria-Amalia Giala
Feb 22, 2003·Surgical Infections·P S Barie, L J Hydo
Feb 27, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Pooja A NawatheJ Scott Baird
Dec 21, 2002·Pharmacotherapy·Judith Jacobi
Sep 5, 2012·Expert Review of Clinical Pharmacology·Juan F FernandezMarcos I Restrepo
Jul 17, 2012·The American Journal of Emergency Medicine·Joaquín R RodeloFabián A Jaimes
Dec 16, 2009·International Journal of Antimicrobial Agents·Ephraim L Tsalik, Christopher W Woods
Dec 5, 2014·Critical Care Medicine·Wendy LimUNKNOWN PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators
Sep 29, 2007·Critical Care Clinics·Michael E EzzieJames M O'Brien
Jan 10, 2006·Critical Care Clinics·Eric S NylénRahul Khosla
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·M KhaleghiI J Kullo
Jul 1, 2004·Thrombosis Research·Matthias W A AngstwurmMichael Spannagl
May 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Edwin ten BoekelWim de Kieviet
Jun 20, 2006·Annals of Emergency Medicine·H Bryant NguyenUNKNOWN Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group
Nov 29, 2005·Journal of Critical Care·Deborah J CookUNKNOWN VTE in the ICU Workshop Participants
May 1, 2015·Revista Portuguesa De Pneumologia·Joana Clemente DuarteArmando Carvalho
Jul 10, 2014·Journal of Thrombosis and Thrombolysis·Rim HalabyC Michael Gibson
Sep 8, 2016·Critical Care Clinics·Lisa RaeNicole Gibran
Nov 18, 2003·Acta Anaesthesiologica Scandinavica·J Hästbacka, V Pettilä
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·David ShitritMoshe Hersch
Jul 4, 2019·Internal and Emergency Medicine·Annalisa BoscoloPaolo Simioni
Nov 14, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yuval ShilonDavid Shitrit
May 13, 2020·Journal of Thrombosis and Thrombolysis·Vittorio PavoniFrancesca Covani Frigieri
May 3, 2021·European Journal of Internal Medicine·Matteo Nicola Dario Di MinnoPasquale Ambrosino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.