A rapid immune response to 2009 influenza A(H1N1) vaccines in adults: a randomized, double-blind, controlled trial

The Journal of Infectious Diseases
Jiang WuWei-Dong Yin

Abstract

A double-blind, randomized, controlled trial involving 706 adults was conducted to evaluate the immunogenicity and safety of different dosages of whole-virion or split-virion H1N1 influenza vaccines with or without aluminum adjuvant. A rapid and strong immune response was induced at day 14 after the first injection. The seroprotection rates ranged from 72.7% (95% confidence interval [CI], 62.7%-81.1%) for 5-microg whole-virion aluminum formulation to 97.0% (95% CI, 90.9%-99.7%) for 30-microg split-virion nonaluminum formulation. All formulations were well tolerated. The incidences of mild, moderate, and severe reactions were 71 (10.1%), 15 (2.1%), and 1 (0.1%) of 706 reactions, respectively. The 15-microg split-virion formulation had the best immunogenicity and safety.

Associated Clinical Trials

Citations

Jul 19, 2011·Emerging Infectious Diseases·James E FieldingHeath A Kelly
Jun 4, 2015·Emerging Microbes & Infections·Zhenglun LiangJunzhi Wang
Jun 15, 2011·Influenza and Other Respiratory Viruses·J Kevin YinRobert Booy
May 6, 2015·The Cochrane Database of Systematic Reviews·Christine ClarKaren Rees
Dec 10, 2014·Expert Review of Vaccines·Vidadi YusibovStephen J Streatfield
Sep 9, 2011·Clinical Trials : Journal of the Society for Clinical Trials·David W ScheifeleScott A Halperin
Feb 24, 2015·Expert Review of Vaccines·Miao XuJunzhi Wang

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