A rapid lateral flow stool antigen immunoassay and (14)C-urea breath test for the diagnosis and eradication of Helicobacter pylori infection in children

Diagnostic Microbiology and Infectious Disease
Zarife KuloğluNurten Girgin

Abstract

Our aim was to evaluate diagnostic accuracy of rapid immunochromatographic stool antigen test (Rapid HpSA; LINEAR Chemical, Barcelona, Spain) and a practical low-dose (14)C urea breath test (UBT) (Heliprobetrade mark) test before and after eradication therapy. One hundred nine children with abdominal symptoms (age range, 5-17 years; mean, 12.1) underwent endoscopy, (14)C-UBT, and Rapid HpSA. Patients were defined as Hp infected when histology was positive for Hp. Forty children (36.6%) were Hp infected. The sensitivity of Rapid HpSA and (14)C-UBT was 65% and 92.5% (P = 0.0003), respectively; the specificity of Rapid HpSA and (14)C-UBT was 92.3% and 85.5% (P = 0.180), respectively. After eradication therapy endoscopy, (14)C-UBT and Rapid HpSA were repeated. The eradication rate was 70.5%. After eradication, the sensitivity of Rapid HpSA and (14)C-UBT was 60% and 100%, respectively; the specificity of Rapid HpSA and (14)C-UBT was 100%. (14)C-UBT was more reliable than the Rapid HpSA test for the diagnosis and for confirming eradication of Hp infection.

References

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Citations

Jul 31, 2010·Nanoscale Research Letters·Hao YangDaxiang Cui
Jul 21, 2009·European Journal of Pediatrics·Jeannette GuarnerSibylle Koletzko
Jul 6, 2010·Revista Do Instituto De Medicina Tropical De São Paulo·Joyce Matie Kinoshita da SilvaRejane Mattar
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Jul 20, 2018·Minerva pediatrica·Fabio CisaròPier Luigi Calvo
Feb 19, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Zeki CalikHalil Yazgi
Aug 29, 2009·Helicobacter·Angelika Kindermann, Ana I Lopes
Aug 29, 2009·Helicobacter·Lurdes MonteiroFrancis Mégraud
Apr 19, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJoaquim Prado de Moraes-Filho
Feb 9, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Parisa SabbaghSoheil Ebrahimpour
Jul 26, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJosé Vitor Zir
Jul 14, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Seiichi KatoUNKNOWN Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition

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