PMID: 6538160Feb 1, 1984Paper

A rapid method for estimating nitrate in biological samples using gas chromatography with a flame-ionization detector or a thermal energy analyzer

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
B J Dull, J H Hotchkiss

Abstract

A simple, rapid method for estimating the nitrate content of biological samples was developed and tested. The method was based on the nitration of benzene under acidic conditions. The resulting nitrobenzene was analysed by gas chromatography with either a flame ionization detector (FID) or a Thermal Energy Analyzer (TEA) for detection. Recovery of nitrate added to urine, blood, saliva or faeces was 96, 97, 96 and 98%, respectively. Coefficients of variation for repeated analyses ranged from 2.2% for saliva to 12% for blood. Sensitivity was of the order of 0.5-1.5 mg/kg for the FID and 0.02-0.05 mg/kg for the TEA.

References

Jul 12, 1975·Lancet·P CorreaM Archer
Jul 1, 1978·Toxicology and Applied Pharmacology·J L RadomskiW L Hearn
Dec 1, 1976·Food and Cosmetics Toxicology·S R TannenbaumD Fett
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May 14, 1982·Journal of Chromatography·J P WitterE Balish
Jan 1, 1980·Oncology·G EisenbrandR Preussmann

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Citations

Nov 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K B ShapiroD A Roe
Oct 1, 1984·Toxicology Letters·B J Dull, J H Hotchkiss
Nov 15, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·S S MirvishE R Lyden
Jun 6, 2002·Human & Experimental Toxicology·N Pant, S P Srivastava
Jan 1, 2006·Disability and Rehabilitation. Assistive Technology·Jon PearlmanMark McCartney
Jan 28, 2009·Disability and Rehabilitation. Assistive Technology·Jon PearlmanAlexandra Jefferds

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