A rapid method for quantification of persistent and mobile organic substances in water using supercritical fluid chromatography coupled to high-resolution mass spectrometry.

Analytical and Bioanalytical Chemistry
Stefanie SchulzeUrs Berger

Abstract

Persistent and mobile organic substances (PM substances) are a threat to the quality of our water resources. While screening studies revealed widespread occurrence of many PM substances, rapid trace analytical methods for their quantification in large sample sets are missing. We developed a quick and generic analytical method for highly mobile analytes in surface water, groundwater, and drinking water samples based on enrichment through azeotrope evaporation (4 mL water and 21 mL acetonitrile), supercritical fluid chromatography (SFC) coupled to high-resolution mass spectrometry (HRMS), and quantification using a compound-specific correction factor for apparent recovery. The method was validated using 17 PM substances. Sample preparation recoveries were between 60 and 110% for the vast majority of PM substances. Strong matrix effects (most commonly suppressive) were observed, necessitating a correction for apparent recoveries in quantification. Apparent recoveries were neither concentration dependent nor dependent on the water matrix (surface or drinking water). Method detection and quantification limits were in the single- to double-digit ng L-1 ranges, precision expressed as relative standard deviation of quadruplicate quanti...Continue Reading

References

Jul 1, 2008·Talanta·Maria Concetta BruzzonitiCorrado Sarzanini
Nov 11, 2008·Journal of Chromatography. a·E Lesellier
Jan 16, 2013·Journal of Bioscience and Bioengineering·Muneo Saito
Aug 1, 2013·Journal of Chromatography. a·Victor Abrahamsson, Margareta Sandahl
Mar 25, 2015·Analytical and Bioanalytical Chemistry·Vilma Del Carmen Salvatierra-StampRoberto Muñiz-Valencia
Aug 27, 2015·Environmental Science and Pollution Research International·Jing TangYanan Wu
Aug 25, 2016·Analytical and Bioanalytical Chemistry·Maria Kristina ParrFrancesco Botrè
Aug 30, 2016·Environmental Science & Technology·Thorsten ReemtsmaPim de Voogt
Feb 13, 2018·Analytical and Bioanalytical Chemistry·Niklas KökeTobias Frömel
Feb 15, 2018·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Vincent DesfontaineDavy Guillarme
Jul 13, 2018·The Science of the Total Environment·Stefanie SchulzeUrs Berger
Feb 23, 2020·Analytical and Bioanalytical Chemistry·Daniel ZahnThomas P Knepper

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