A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic outcomes from observational studies

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Penelope A BradburyGeoffrey Liu

Abstract

Case-control and observational studies are popular choices for evaluating molecular prognostic/pharmacogenetic outcomes, but data quality is rarely tested. Using clinical trial and epidemiologic methods, we assessed the quality of prognostic and outcomes data obtainable from a large case-control study of lung cancer. We developed an explicit algorithm (set of standard operating procedures forming a rapid outcomes ascertainment system) that encompassed multiple tests of quality assurance, and quality of data for a range of prognostic and outcomes variables, in several cancers, across several centers and two countries were assessed. Based on these assessments, the algorithm was revised and physicians' clinical practice changed. We reevaluated the quality of outcomes after these revisions. Development of an algorithm with internal quality controls showed specific patterns of data collection errors, which were fixable. Although the major discrepancy rate in retrospective data collection was low (0.6%) when compared with external validated sources, complete data were found in <50% of patients for treatment response rate, toxicity, and documentation of patient palliative symptoms. Prospective data collection and changes to clinical p...Continue Reading

Citations

Dec 1, 2012·Journal of the National Cancer Institute·Joanne W ElenaAndrew N Freedman
Jul 22, 2009·Pharmacogenetics and Genomics·Penelope A BradburyGeoffrey Liu
Apr 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David W CesconGeoffrey Liu
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Penelope A BradburyGeoffrey Liu
Apr 7, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karen WongJolie Ringash
Jun 11, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Graeme P Williams
Oct 23, 2009·Molecular Oncology·Catherine Gérard, Channa Debruyne
Aug 4, 2016·International Journal of Cancer. Journal International Du Cancer·Maja SegediSean P Cleary
Jan 16, 2017·Cancer Epidemiology·Anna SpreaficoGeoffrey Liu

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