A rapid quantitative D-dimer assay at admission correlates with the severity of community acquired pneumonia

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Yuval ShilonDavid Shitrit

Abstract

Previous research has shown a link between infectious inflammatory processes and hemostatic abnormalities. No data exist, however, on whether coagulation markers correlate with the severity of community-acquired pneumonia (CAP) at admission. We conducted a prospective, observational study in an Emergency Medicine Department of a primary care hospital. Sixty-eight patients admitted with CAP were included. Blood samples were collected at admission and assayed for D-dimer levels. D-dimers were correlated with the Pneumonia Patient Outcome Research Team (PORT) score and Acute Physiology and Chronic Health Evaluation II score on admission, with length of hospital stay, number of organ failures, time to defervescence and hospital mortality. D-dimer levels were positively correlated with the Acute Physiology and Chronic Health Evaluation II score (r = 0.44, P = 0.0002), the PORT score (r = 0.36, P = 0.002) and the length of hospital stay (r = 0.24, P = 0.046). Mean D-dimer levels of patients for whom hospitalization is recommended, according to PORT guidelines, were significantly higher than D-dimer levels of patients for whom hospitalization is not recommended (1.47 +/- 1.05 microg/ml and 0.71 +/- 0.79 microg/ml respectively; P = 0.0...Continue Reading

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Citations

Sep 16, 2009·Molecular Medicine·Eric B MilbrandtUNKNOWN GenIMS Investigators
Jan 15, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·D ShitritM R Kramer
Aug 2, 2020·Annals of Intensive Care·Jiao LiuDechang Chen
Jul 10, 2014·Journal of Thrombosis and Thrombolysis·Rim HalabyC Michael Gibson
May 14, 2020·Archives of Medical Research·Megan Carolina Cerda-MancillasIrma Isordia-Salas

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