PMID: 2124259Oct 1, 1990Paper

A rapid redistribution of hydrogen ions is associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion

Journal of Neurophysiology
T P ObrenovitchL Symon

Abstract

1. The aim of this study was to examine the rapid changes in extracellular hydrogen ion activity [( H+]o or pHo) which are associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion. Two parallel studies were performed with different rat models of ischemia: repetitive severe ischemia produced in anesthetized animals by occlusion of the vertebral and carotid arteries and temporary interruption of blood flow in isolated brain. [H+]o and direct current potential (DC potential) were recorded simultaneously in all experiments. Examination of these two parameters was supplemented by recording tissue concentration of carbon dioxide (PtCO2) in the four-vessel occlusion model and assaying major metabolites involved in energy production in experiments with isolated brains. 2. Measurements of [H+]o during ischemia consistently revealed a steady increase of [H+]o on which was superimposed an abrupt and transient fall in [H+]o closely related to the occurrence of the fast negative shift of DC potential characterizing brain-cell depolarization. Analysis of the relationship between the magnitude of the transient fall in H+ and the level of [H+]o at which this occurred showed that the amplitude of the transie...Continue Reading

Citations

Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·Y UedaL Symon
Jun 11, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martin D KingDavid G Gadian
Apr 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Olena YermolaievaMichael J Welsh
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N G HarrisS R Williams
Nov 30, 1999·Journal of Neurosurgery·T SorimachiR Tanaka
Sep 1, 2016·Translational Stroke Research·Emiri T MandevilleJoseph B Mandeville
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chengli LingJianxin Wang
Oct 16, 1999·Journal of Neurotrauma·N PlesnilaF Staub
Feb 16, 1999·Brain Pathology·D L TaylorH Mehmet
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y XieF Tegtmeier
Jan 1, 1999·Amino Acids·J Urenjak, T P Obrenovitch
Oct 3, 1999·Physiological Reviews·P Lipton
Apr 27, 2002·Journal of Neurophysiology·Claire Sheldon, John Church
May 1, 1993·Stroke; a Journal of Cerebral Circulation·Y MarukiR J Traystman
Sep 1, 1996·Neurochemical Research·D L TaylorL Symon

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