PMID: 7993149Dec 12, 1994Paper

A rapid test for infectious and inflammatory enteritis

Archives of Internal Medicine
J R MillerR L Guerrant

Abstract

Inflammatory illnesses are an indication for specific diagnostic studies and possible antimicrobial therapy. The presence of fecal leukocytes has been used as a marker of inflammatory diarrhea; however, microscopic examination of the fecal smear is unreliable if the specimen is transported, refrigerated, frozen, or collected by swab. To evaluate a rapid, sensitive, semiquantitative test for detection of fecal leukocytes using antilactoferrin latex bead agglutination (LFLA), a test that remains sensitive even after specimens are refrigerated, frozen, or stored on swabs. LFLA titers were determined in stool specimens from previously healthy volunteers before and after experimental infection with different enteric pathogens and from patients with nosocomial diarrhea caused by Clostridium difficile. Healthy controls and subjects with noninflammatory diarrhea caused by Vibrio cholerae consistently demonstrated LFLA titers less than 1:50. In contrast, subjects with inflammatory diarrhea caused by Shigella species and C difficile had markedly elevated titers. Titers for subjects with experimental shigellosis ranged from 1:50 to 1:3200, with seven (78%) of nine at 1:400 or greater. Titers for patients with C difficile enteritis ranged ...Continue Reading

Citations

Jan 4, 2001·Journal of Clinical Microbiology·K L SavolaD J Passaro
Dec 23, 2003·Infection and Immunity·Xin ZhouJames B Kaper
Mar 9, 2004·Journal of Clinical Microbiology·L A GranvilleJ R Davis
Jul 5, 2013·Clinical Microbiology Reviews·Carey-Ann D Burnham, Karen C Carroll
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R L GuerrantUNKNOWN Infectious Diseases Society of America
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher J GillDavidson H Hamer
Feb 27, 2015·Pathology·Deirdre A CollinsThomas V Riley
Apr 11, 2015·International Journal of Microbiology·Gustavo VarelaFelipe Schelotto
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Mar 1, 1996·Microbiological Reviews·C L Sears, J B Kaper
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