A rapid UHPLC-MS/MS method for simultaneous quantitation of 23 perfluoroalkyl substances (PFAS) in estuarine water

Talanta
Vanisree MulabagalJoel S Hayworth

Abstract

Per- and polyfluoroalkyl substances (PFAS) represent a large group of synthetic organic compounds which, as a result of their unique chemical properties, render them extremely recalcitrant to environmental degradation. Research concerning the environmental, ecological, and human health effects of PFAS has focused on long aliphatic chain (> C7) compounds having no ether bonds. For new, less studied, or previously unknown PFAS (≤ C7 with ether bonds), there is little to no information about their environmental behavior, transport, fate, exposure, and toxicological effects. LC-MS/MS has proven effective for detection and quantitation of some PFAS, however, straightforward analytical methods for simultaneous trace quantitation of broad mixtures of PFAS in varied complex environmental media, available to a wide range of researchers and also suitable for routine monitoring, remain critical needs. Here we describe a simple, rapid, sensitive, and reproducible quantitative analytical method for trace analysis and monitoring of 23 PFAS in estuarine water, using ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS). The developed MRM method allows simultaneous trace quantitation of a broad mixture ...Continue Reading

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