A Rare Case of Drug-Induced Erectile Dysfunction with Secukinumab Solved After Switch to Ixekizumab in A Psoriatic Patient: A Case Report

Current Drug Safety
Stefano DastoliEmilio Russo

Abstract

Psoriasis is a cutaneous inflammatory condition characterized by an altered turnover of keratinocytes leading to scaly patches. Secukinumab and ixekizumab are two biologic drugs inhibiting interleukin-17. We report the first case, according to Naranjo score, of a secukinumab-induced erectile dysfunction with severe plaque psoriasis that disappeared after switching to another anti IL17 drug (ixekizumab). A 45 years old man experienced erectile dysfunction during treatment with an anti-IL17. The adverse effect appeared after 60 days of treatment with secukinumab and rapidly disappeared after discontinuation of the drug. All necessary urologic exams were carried out. Re-administration of secukinumab, due to the exacerbation of psoriasis, caused the same sexual dysfunction after 60 days. Switching to ixekizumab lead to a resolution of the erectile dysfunction and a complete skin clearance. We describe for the first time a sexual dysfunction possibly due to secukinumab and its resolution after the switch to another similar but different drug, highlighting the potential difference between anti-IL17A drugs.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Apr 1, 2015·Journal of the American Academy of Dermatology·Caitriona RyanAlan Menter
Oct 18, 2016·Rheumatology and Therapy·Philip Mease, Iain B McInnes
Nov 25, 2016·Nature Reviews. Disease Primers·Jacqueline E GrebAlice B Gottlieb
Jun 18, 2017·Andrology·M SemetJ Perrin
Jan 19, 2018·Therapeutic Advances in Chronic Disease·Jillian FriederAlan Menter
May 23, 2018·The British Journal of Dermatology·C Paul

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Citations

Jun 3, 2021·Healthcare·Giuseppe Fabrizio AmorusoLuigi Bennardo

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