A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult

Case Reports in Infectious Diseases
Foula VassilaraAntonios Papadopoulos

Abstract

Human coronavirus 229E (HCoV-229E) is one of the first coronavirus strains being described. It is linked to common cold symptoms in healthy adults. Younger children and the elderly are considered vulnerable to developing lower respiratory tract infections (LRTIs). In particular, immunocompromised patients have been reported with severe and life-threatening LRTIs attributed to HCoV-229E. We report for the first time a case of LRTI and acute respiratory distress syndrome developed in a healthy adult with no comorbidities and HCoV-229E strain identified as the only causative agent. A 45-year-old female with a clear medical history presented with fever, cough, and headache. Respiratory tract infection was diagnosed, and empirical antibiotics were started. Within two days, she developed bilateral pleural effusions, diffuse consolidations, and ground glass opacities involving all lung fields. She needed immediate oxygen supply, while ABGs deteriorated and chest imaging and PaO2/FiO2 indicated ARDS. Early administration of systemic corticosteroids led to gradual clinical improvement. Multiplex PCR from nasal secretions was positive only for HCoV-229E and negative for multiple other pathogens. It remains to be elucidated how an immunoc...Continue Reading

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Citations

May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Keykavous ParangRakesh K Tiwari
Dec 2, 2020·Emerging Topics in Life Sciences·Ny Anjara Fifi RavelomanantsoaCara E Brook
Dec 6, 2020·Applied and Environmental Microbiology·Charles F Dillon, Michael B Dillon
Nov 7, 2020·Frontiers in Immunology·Conor McClenaghanColin G Nichols
Jun 15, 2021·Frontiers in Microbiology·Priyanka MehtaRajesh Pandey
Aug 26, 2021·Journal of Infection and Public Health·Tahmeena FarooqiSirajudheen Anwar

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