Abstract
Human coronavirus 229E (HCoV-229E) is one of the first coronavirus strains being described. It is linked to common cold symptoms in healthy adults. Younger children and the elderly are considered vulnerable to developing lower respiratory tract infections (LRTIs). In particular, immunocompromised patients have been reported with severe and life-threatening LRTIs attributed to HCoV-229E. We report for the first time a case of LRTI and acute respiratory distress syndrome developed in a healthy adult with no comorbidities and HCoV-229E strain identified as the only causative agent. A 45-year-old female with a clear medical history presented with fever, cough, and headache. Respiratory tract infection was diagnosed, and empirical antibiotics were started. Within two days, she developed bilateral pleural effusions, diffuse consolidations, and ground glass opacities involving all lung fields. She needed immediate oxygen supply, while ABGs deteriorated and chest imaging and PaO2/FiO2 indicated ARDS. Early administration of systemic corticosteroids led to gradual clinical improvement. Multiplex PCR from nasal secretions was positive only for HCoV-229E and negative for multiple other pathogens. It remains to be elucidated how an immunoc...Continue Reading
References
Jan 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D Hamre, J J Procknow
Nov 1, 1974·The Journal of Infectious Diseases·K McIntoshM A Mufson
May 1, 1972·The American Review of Respiratory Disease·J O HendleyJ M Gwaltney
Apr 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·K McIntoshR M Chanock
Sep 23, 1967·British Medical Journal·A F BradburneD A Tyrrell
Nov 21, 1997·BMJ : British Medical Journal·K G NicholsonE Cancio
Feb 18, 1998·Journal of Clinical Microbiology·M J MäkeläP Arstila
Mar 20, 1999·Chest·R J Folz, M A Elkordy
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Sep 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frédéric PenePierre Lebon
Jan 16, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Giuseppe GernaFausto Baldanti
Oct 9, 2007·The Journal of Infectious Diseases·Ryan K DareDean D Erdman
Jun 18, 2010·Journal of Clinical Microbiology·E R GauntK E Templeton
Jul 17, 2012·JAMA : the Journal of the American Medical Association·V Marco RanieriArthur S Slutsky
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Jan 15, 2013·Journal of Virological Methods·Manohar L ChoudharyAkhilesh C Mishra
Aug 8, 2013·The Journal of Infectious Diseases·Edward E WalshAnn R Falsey
Jan 1, 2016·American Journal of Respiratory and Critical Care Medicine·Ori GalanteYaniv Almog
Citations
May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Keykavous ParangRakesh K Tiwari
Dec 12, 2018·Microbiology Resource Announcements·Kai LiYuxin Tang
Dec 2, 2020·Emerging Topics in Life Sciences·Ny Anjara Fifi RavelomanantsoaCara E Brook
Dec 6, 2020·Applied and Environmental Microbiology·Charles F Dillon, Michael B Dillon
Nov 7, 2020·Frontiers in Immunology·Conor McClenaghanColin G Nichols
Mar 18, 2021·BioMed Research International·Hong-Mei ShuZhen-Jun Liu
Jun 15, 2021·Frontiers in Microbiology·Priyanka MehtaRajesh Pandey
Aug 26, 2021·Journal of Infection and Public Health·Tahmeena FarooqiSirajudheen Anwar