A rare case of interstitial pneumonitis after tandem high-dose melphalan conditioning and autologous stem cell transplantation in multiple myeloma

European Journal of Haematology
Veronika Buxhofer-AuschWolfgang Hinterberger

Abstract

A 57-yr-old woman with multiple myeloma received an autologous tandem transplant at a 4-month interval. She was conditioned twice with 225 mg/m2 melphalan. After the second transplant, interstitial pneumonitis (IP) ensued. The clinical course was life threatening and mechanical ventilation was required for 32 d. All attempts to identify an infectious agent failed. A presumptive diagnosis of idiopathic IP, possibly related to melphalan toxicity, was made. High-dose methylprednisolone administration led to rapid and durable improvement. Melphalan was employed for conditioning in the tandem setting with an interval of only 3-4 months between two courses or a dose elevation to 225 instead of 200 mg/m2, may have induced IP which responded favorably to methylprednisolone.

References

Aug 1, 1972·Journal of Clinical Pathology·B W Codling, T M Chakera
Jun 1, 1980·Chest·G GoucherJ Hawkins
Jan 1, 1995·Seminars in Roentgenology·J M Aronchick, W B Gefter
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·S W MalikU Specks
Sep 23, 2000·Baillière's Best Practice & Research. Clinical Haematology·G Salles, B Coiffier
Jul 4, 2001·Bone Marrow Transplantation·T R Spitzer

❮ Previous
Next ❯

Citations

Nov 8, 2012·Case Reports in Pulmonology·E VandeixM Clavel
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Renata E ZauchaWilliam I Bensinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.