A rare case of plasmacytoma-like post-transplant lymphoproliferative disorder presenting in the skin of a lung transplant patient

Journal of Cutaneous Pathology
R McFarlaneZ Argenyi

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is a lymphoid proliferation that develops as a complication of solid organ or bone marrow transplants. Most cases usually present in the gastrointestinal tract, liver, kidney or lymph nodes. Plasmacytoma-like PTLD is an uncommon variant, and presentation in the skin is exceedingly rare. We present a case of plasmacytoma-like PTLD presenting as a leg mass in a 58-year-old male. Biopsy from the lesion exhibited atypical plasmacytoid and plasmablastic cells that showed lambda light chain restriction and stained positive for CD138 and Epstain-Bar virus early RNA by in situ hybridization. These findings were diagnostic of plasmacytoma-like PTLD. Only a few similar cases have been reported in the literature. The majority of these cases occurred in heart and kidney transplant patients. To our knowledge, this is the first reported case to occur in a lung transplant patient.

References

Oct 23, 1997·Hematology/oncology Clinics of North America·L J Swinnen
Apr 18, 2000·Journal of the American Academy of Dermatology·K W SchumannK Hollandsworth
Jun 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P RamalingamE D Hsi
Oct 25, 2003·Journal of the American Academy of Dermatology·Theresa R PachecoJames Fitzpatrick
Nov 18, 2003·The British Journal of Dermatology·I NicolM A Richard
Jun 10, 2004·Journal of Cutaneous Pathology·Nancy J SamolitisRonald M Harris
Sep 24, 2004·Archives of Dermatology·David Beynet, Anthony E Oro
Dec 24, 2004·International Journal of Hematology·Gianpaolo TessariAnnalisa Barba
Feb 5, 2005·Annales de dermatologie et de vénéréologie·A CarbonnelleS Fraitag
Feb 5, 2005·Annales de dermatologie et de vénéréologie·M BuffetUNKNOWN Groupe Français D'Etude Des Lymphomes Cutanés
Oct 3, 2006·The American Journal of Dermatopathology·Vickie WilloughbyLudvik R Donner

❮ Previous
Next ❯

Citations

Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Jul 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Amir A BorhaniMichael Nalesnik
May 12, 2012·Journal of Cutaneous Pathology·Ana M Molina-RuizLuis Requena
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Aghil Gholipour-ShoiiliSaeed Taheri
Nov 2, 2016·Genes, Chromosomes & Cancer·Clémentine SarkozyJulie Bruneau
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tzu-Fei WangGeoffrey L Uy
Sep 19, 2009·American Journal of Clinical Pathology·Bill G RichendollarJames R Cook
Apr 27, 2021·The American Journal of Dermatopathology·Ashley P CraddockShyam S Raghavan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.