A Ras subfamily GTPase shows cell cycle-dependent nuclear localization

EMBO Reports
B W SutherlandGerald Weeks

Abstract

Previously characterized Ras subfamily proteins have been found to be predominantly associated with the plasma membrane where they function in signal transduction pathways to convey extracellular signals to intracellular targets. Here, we provide evidence that the Dictyostelium Ras subfamily protein RasB has a novel subcellular localization and function. The protein is predominantly localized in the nucleus during most of the cell cycle. Furthermore, during mitosis and cytokinesis RasB assumes a diffuse cellular localization despite the fact that the nuclear membrane stays intact. The linkage between the position of RasB in the cell and division suggests that it may have a role in nuclear division. Consistent with this idea, rasB- cells exhibit severe growth defects and cells overexpressing an activated version of RasB are multinucleate.

References

Jan 1, 1976·The Journal of Cell Biology·P B Moens
Sep 1, 1970·The Biochemical Journal·D J Watts, J M Ashworth
Aug 11, 1997·The Journal of Cell Biology·R I TuxworthR H Insall
Oct 6, 1997·Genes & Development·L Van Aelst, C D'Souza-Schorey
Mar 14, 2000·Current Opinion in Cell Biology·G W Reuther, C J Der
Mar 31, 2000·Trends in Cell Biology·J M ShieldsC J Der
Jan 12, 2001·Physiological Reviews·Y TakaiT Matozaki
Mar 21, 2001·Biochimica Et Biophysica Acta·J R Chubb, R H Insall
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·M J HendzelD P Bazett-Jones

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Citations

May 10, 2005·Experimental Cell Research·Chinten James LimGerald Weeks
Jul 23, 2003·Cellular Signalling·Gerald Weeks, George B Spiegelman
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Dae-Young KangYong-Sung Kim
May 23, 2014·Cellular and Molecular Life Sciences : CMLS·Yulia ArtemenkoPeter N Devreotes
May 28, 2008·The Journal of Cell Biology·Subhanjan MondalAngelika A Noegel
May 15, 2004·EMBO Reports·Helmut KaeGerald Weeks
Mar 13, 2014·Biological Reviews of the Cambridge Philosophical Society·Danton H O'Day, Aldona Budniak
Apr 4, 2008·Cellular Signalling·Arjan Kortholt, Peter J M van Haastert
Nov 7, 2012·The International Journal of Biochemistry & Cell Biology·Serena BroggiSonia Colombo
Feb 12, 2014·Biochemical and Biophysical Research Communications·Hyemin MunTaeck J Jeon
Jul 6, 2014·BMC Cell Biology·Annette Müller-TaubenbergerGerald Weeks
Jun 14, 2006·The Journal of Biological Chemistry·Arjan KortholtPeter J M Van Haastert
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas D WilliamsRobert R Kay
Jul 28, 2013·Journal of Cell Science·Arjan KortholtPeter J M Van Haastert

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