A rat esophageal model to investigate stent-induced tissue hyperplasia

Journal of Vascular and Interventional Radiology : JVIR
Eun-Young KimHo Young Song

Abstract

To evaluate the feasibility of stent placement and the formation of tissue hyperplasia caused by stent placement in a rat esophageal model. Twenty Sprague-Dawley rats were divided into four groups to assess differing stent diameters and design (group I, 4 mm diameter and a large mesh gap; group II, 5 mm diameter and a large mesh gap; group III, 5 mm diameter and a small mesh gap; and group IV, barbs added to the group III stents). Follow-up, 1-week, and 3-week esophagograms were obtained. Rats were euthanized 3 weeks after stent placement. Microscopic findings were evaluated in groups with an incidence of less than 50% stent migration. Stent placement was technically successful in all rats, and there were no procedure-related complications. No esophageal perforation occurred during follow-up. The incidence of stent migration was 100%, 60%, 40%, and 0% in groups I through IV, respectively. The esophagi with stent migration showed only a small amount of tissue hyperplasia; however, esophagi without stent migration showed gross tissue hyperplasia through the mesh. The microscopic findings were evaluated in groups III and IV. The degree of inflammatory cell infiltration, papillary projection thickness, granulation tissue area, and ...Continue Reading

References

Mar 14, 1998·Journal of Pediatric Surgery·R M FillerP Chait
Jun 2, 2000·Journal of Vascular and Interventional Radiology : JVIR·S H DudaC D Claussen
Jul 6, 2000·Basic Research in Cardiology·C IndolfiM Chiariello
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Je Hwan WonKyong-Min Shin
Sep 26, 2002·Journal of Vascular Research·Aloke V FinnFrank D Kolodgie
Apr 23, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Scott A ZakaluznyEric A Mair
Sep 18, 2004·Journal of Vascular Research·Bas LangeveldWiek H van Gilst
Feb 16, 2005·Heart·H C LoweL M Khachigian
Jul 25, 2006·Gastrointestinal Endoscopy·Todd H BaronNicole L Pochron
Nov 7, 2006·European Journal of Radiology·Jin-He GuoJie He

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Citations

Aug 8, 2018·ACS Applied Materials & Interfaces·Jung-Hoon ParkHo-Young Song

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