A rat model for studying effects of sacral neuromodulation on the contractile activity of a chronically inflamed bladder

BJU International
Seyed-Hossein Riazimand, Siegfried Mense

Abstract

To develop an animal model in which the effects of electrical stimulation of the sacral nerves (sacral neuromodulation) on a chronic hyperactive urinary bladder can be studied. In female rats the urinary bladder was instilled with mustard oil (0.4%); after 10 days the animals were anaesthetized with intraperitoneal urethane, the bladder catheterized and connected to a pressure transducer. Stimulating electrodes were placed into the sacral foramina bilaterally. The intensity and duration of sacral electrical stimulation was varied systematically to determine the effects of the sacral neuromodulation on bladder contractions. The main effect of the neuromodulation was an increase in the interval between contractions, i.e. during and for some time after the stimulation the contractions were completely abolished. The duration of the pause increased with the intensity and duration of stimulation. After the contractions had reappeared the frequency of contractions was reduced for a long period. In animals with chronic cystitis the effects of neuromodulation tended to be stronger (the pauses were longer) than in control animals with an intact bladder, but only in one test (increase of pause length with stimulus duration) was the differ...Continue Reading

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Citations

Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Robert D Mayer, Fred M Howard
Nov 13, 2008·Nature Clinical Practice. Urology·Thomas M Kessler, Clare J Fowler
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G GourcerolM Bouvier
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Jun 12, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Sükrü KumsarHakan Ozkardeş
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Mar 14, 2008·International Journal of Immunopathology and Pharmacology·D MinardiG Muzzonigro
Jan 4, 2013·American Journal of Physiology. Renal Physiology·Fan ZhangChangfeng Tai

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