A rat model of a repeat 70% major hepatectomy

The Journal of Surgical Research
Shuji SaitoHiroshi Shimada

Abstract

This study investigated the effects of a repeat 70% major hepatectomy in a rat model. The left lateral and median lobes of the livers of 80 seven-week-old male Wistar rats were excised during primary hepatectomy, removing a total of 70% of the liver. In 40 of the rats, the regenerated right lateral lobe, comprising 70% of the remnant liver, was excised during secondary hepatectomy 7 days after the initial procedure. The survival rate, posthepatectomized regeneration ratio, and laboratory blood data were compared between the groups that had undergone initial only and repeat hepatectomies. All of the rats survived for at least 7 days after each procedure. The remaining liver returned to up to about 90% of its original wet weight by 5 days in both groups. The serum glutamic-pyruvic transaminase levels peaked 12 h after hepatectomy, remained at a similar level at 36 h, and had normalized by 2 days. Serum total bilirubin levels were similar in both groups. The total cell numbers after 5 days were significantly higher in the initial hepatectomy group than in the repeat hepatectomy group. We established a rat model in which an initial 70% major hepatectomy was followed by a repeat 70% major hepatectomy of the regenerated liver. The ti...Continue Reading

References

Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NaginoH Yamamoto
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N YamanakaW Tanaka
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C GerlachJ Gerdes
Oct 1, 1963·The Journal of Pathology and Bacteriology·G E SIMPSON, E S FINCKH
Jan 10, 2004·Langenbeck's Archives of Surgery·Hiroshi ShimadaShinji Togo
May 27, 2005·The Journal of Surgical Research·Hirochika MakinoHiroshi Shimada
Dec 24, 2005·Annals of Surgery·Yuman Fong, David J Bentrem

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Citations

Apr 17, 2015·Journal of Hepato-biliary-pancreatic Sciences·Natsuko F InagakiAtsushi Miyajima

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