A rat model of knee osteoarthritis suitable for electroacupuncture study

Experimental Animals
Yongyuan MaLize Xiong

Abstract

Acupuncture is widely used for knee osteoarthritis (KOA) treatment in clinical practice. In the present study, we aimed to set a standard KOA animal model for electroacupuncture (EA) study and provide an acupuncture recipe for further KOA studies. Rats intra-articularly administered monosodium iodoacetate (MIA, 0.3, 1 or 3 mg respectively, n=12 each) were evaluated for pain-like behavior: paw withdrawal mechanical threshold, weight bearing deficit, and joint pathological changes (OARSI score) until 28 days after injury. Then by using the suitable dose (1 mg MIA), therapeutic effects of EA treatment (bilateral ST36 and ST35 acupoints, 2/10 Hz, 30 min/d, 6d/w, 2w) were evaluated in 3 groups (n=16 each): Early-on EA, Mid-term EA and Delayed EA, in which EA was started on day 1, day 7 or day 14 after MIA injection. Both 1 mg and 3 mg MIA induced significant joint damage and persistent pain behavior. But animals accepted 3 mg MIA rapidly developed cartilage and bone damage within 14 days. Early-on EA treatment provided significant pain relief and joint structure preservation in KOA rats. Mid-term EA treatment only reduced pain, while delayed EA treatment resulted in no effects in both aspects. 1 mg of MIA produces steady pain behavi...Continue Reading

References

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Citations

Sep 25, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Yuan LiXueyong Shen
Mar 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Fuhai BaiLize Xiong
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yu ChenChunsheng Jia
Jun 10, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Alexa P SpittlerKelly S Santangelo
Jul 19, 2021·Clinical and Experimental Pharmacology & Physiology·Felicity Y HanMaree T Smith

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