A ratiometric electrochemical sensor for selectively monitoring monoamine oxidase A in the live brain.

Chemical Communications : Chem Comm
Chuanping ZhangYang Tian

Abstract

Herein, an electrochemical method for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain was reported. Using this tool, it was found that MAO-A increased Ca2+ entry into neurons via the TPRM2 channel in the live mouse brain of an AD model.

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