Abstract
A turn-on fluorometric probe is described for the β-thalassemia drug deferiprone (DFP). The probe is making use of carbon dots (C-dots) and gold nanoclusters (AuNCs) which, under 340-nm excitation, display dual emission with peaks at 445 and 592 nm. The orange fluorescence of AuNCs is quenched after the addition of Fe(III), but recovered on addition of DFP. The blue fluorescence of the C-dots, in contrast, remains unchanged. The Fe(III)-DFP complex undergoes intermolecular electron transfer under UV excitation and displays only weak peaks in the UV region. The ratio of the two fluorescences is measured which makes the probe intrinsically self-calibrated. Colorimetry is best performed at a wavelength of 280 nm. The ratio of fluorescences increases linearly in the 0.1-80 μM DFP concentration range, and the detection limit is 0.1 μM. The respective figures for colorimetry are 2.5-120 μM and 0.3 μM. The probe is highly selective for DFP. Thus, it possesses a large potential for detection of DFP in serum. Graphical abstract The orange fluorescence of gold nanoclusters (AuNCs) is quenched by Fe3+ ions but recovered on addition of deferiprone (DFP), while the change of blue fluorescence in carbon dots (C-dots) is minimal. Moreover, th...Continue Reading
References
Nov 21, 2007·Analytical Biochemistry·M HajjizadehK Karimian
Aug 20, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Jamshid L ManzooriAbolghasem Jouyban
Mar 1, 2012·Analytical Chemistry·Ja-an Annie HoWen-Ta Su
Mar 30, 2012·Biomedical Chromatography : BMC·Ta-Shu SongMann-Jen Hour
Jun 19, 2013·Biosensors & Bioelectronics·Xiaoyu MuHuimin Ma
Aug 28, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M S Seyed DorrajiM H Rasoulifard
Oct 16, 2014·Chemical Society Reviews·Shi Ying LimZhiqiang Gao
Feb 24, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Kraivinee PragourpunSenee Kruanetr
Sep 24, 2015·Nanoscale·Jian SunXiurong Yang
Apr 20, 2016·Biosensors & Bioelectronics·Hao-Hua DengWei Chen
May 18, 2016·Nanoscale·Juan HouLan Ding
Jun 13, 2016·Biosensors & Bioelectronics·Jessica Fung Yee FongSing Muk Ng
Jul 26, 2017·Talanta·Jingjing JiangShaomin Shuang
Mar 30, 2018·Mikrochimica Acta·Menghuan TangHuzhi Zheng
Apr 15, 2018·Mikrochimica Acta·Yuan XuYanhua Chen
May 8, 2018·Mikrochimica Acta·Yanying WangHanbing Rao
May 20, 2018·Mikrochimica Acta·Dongqin YangJilin Yan
Jul 30, 2018·Mikrochimica Acta·Shan HuangQi Xiao
Citations
Nov 22, 2019·Mikrochimica Acta·Xia ChengYao Cen
Mar 17, 2021·The Analyst·Hafiz Muhammad JunaidMadeeha Batool
Jan 22, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiajia WuZhili Peng