Abstract
Reactive oxygen species (ROS) are important mediators in a variety of pathological events, but the oxidative stress owing to excessive generation of ROS is implicated in many human diseases. In this work, we designed and synthesized a novel dual-functional chelating ligand, [4'-(p-aminophenoxy)methylene-2,2':6',2''-terpyridine-6,6''-diyl]bis(methylenenitrilo)tetrakis(acetic acid) (AMTTA), that can strongly coordinate with both Eu(3+) and Tb(3+) in aqueous solutions for the recognition and time-gated luminescence detection of highly ROS (hROS), hydroxyl radical ((•)OH), and hypochlorite (ClO(-)). The complexes AMTTA-Ln(3+) (Ln = Eu and Tb) are almost nonluminescent because of the photoinduced electron transfer from the electron-rich aminophenyl group to the terpyridine-Ln(3+) moiety but can rapidly react with hROS to afford highly luminescent complexes (4'-hydroxymethyl-2,2':6',2''-terpyridine-6,6''-diyl)bis(methylenenitrilo)tetrakis(acetate)-Ln(3+) (HTTA-Ln(3+)). Interestingly, when the AMTTA-Eu(3+)/Tb(3+) mixture (AMTTA/Eu(3+)/Tb(3+) = 2/1/1) was reacted with hROS, the intensity ratio of its Tb(3+) emission at 540 nm to its Eu(3+) emission at 610 nm, I(540)/I(610), showed a ratiometric response toward hROS, and the dose-depend...Continue Reading
References
Aug 9, 1974·Science·J M McCord
Feb 1, 1994·Free Radical Biology & Medicine·N W KooyJ S Beckman
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·P KuppusamyJ L Zweier
Jan 1, 1996·The Biochemical Journal·H Wiseman, B Halliwell
Jan 1, 1995·Chemistry & Biology·K N SchmidtP A Baeuerle
Oct 10, 1998·Brain Research. Brain Research Protocols·B LeiT Arai
Aug 12, 1999·Free Radical Biology & Medicine·S L HempelD M Flaherty
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·O YermolaievaT Hoshi
Mar 1, 2000·Biochemical and Biophysical Research Communications·H Yasui, H Sakurai
May 10, 2000·FEBS Letters·K U Fröhlich, F Madeo
May 23, 2000·Molecular and Cellular Biochemistry·K DobashiA K Singh
Dec 2, 2000·Nature·M NishidaH Kurose
Nov 7, 2002·The Journal of Biological Chemistry·Ken-ichi SetsukinaiTetsuo Nagano
Mar 12, 2005·The Journal of Organic Chemistry·Chantal GalaupClaude Picard
Aug 18, 2005·Chemistry : a European Journal·Anne PetitjeanJean-Marie Lehn
May 4, 2006·Journal of the American Chemical Society·Dan YangJian-Gang Shen
May 18, 2006·Journal of the American Chemical Society·Kazuki KiyoseTetsuo Nagano
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Sep 21, 2006·Journal of the American Chemical Society·Louise K CharkoudianKatherine J Franz
Oct 7, 2006·Chemical Communications : Chem Comm·Robert A PooleDavid Parker
Oct 13, 2006·Journal of the American Chemical Society·Bo SongJingli Yuan
Oct 31, 2006·Chemistry : a European Journal·Kehua XuLiguo An
Apr 3, 2007·Nature Chemical Biology·Evan W MillerChristopher J Chang
May 24, 2007·Journal of the American Chemical Society·Matthew S TremblayDalibor Sames
Aug 4, 2007·Journal of the American Chemical Society·Yuichiro KoideTetsuo Nagano
Sep 13, 2007·Nature Reviews. Molecular Cell Biology·Benoît D'Autréaux, Michel B Toledano
Mar 14, 2008·Journal of the American Chemical Society·Duangkhae SrikunChristopher J Chang
Apr 19, 2008·Nature Chemical Biology·Christine C Winterbourn
Sep 17, 2008·Angewandte Chemie·Xiaolin ZhangXuhong Qian
Jan 22, 2009·Chemistry : a European Journal·Weiying LinWen Tan
Dec 22, 2009·Chemical Communications : Chem Comm·Ga-Lai LawKa-Leung Wong
May 21, 2010·Chemistry : a European Journal·Cuihong SongYafeng Guan
Dec 25, 2010·Journal of the American Chemical Society·David J LewisZoe Pikramenou
Dec 28, 2010·Nature Chemical Biology·Bryan C DickinsonChristopher J Chang
Jul 20, 2011·Nature Chemical Biology·Bryan C Dickinson, Christopher J Chang
Citations
May 15, 2013·Analytical and Bioanalytical Chemistry·Margaret A DonoghueEdgar A Arriaga
Dec 18, 2013·Chemical Reviews·Marie C HeffernThomas J Meade
Aug 31, 2014·Journal of Fluorescence·Zhiqiang YeJingli Yuan
Aug 10, 2013·Photochemistry and Photobiology·Qiu-Ping Li, Bing Yan
May 29, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Natalia SelivanovaYury Galyametdinov
Dec 28, 2016·ACS Applied Materials & Interfaces·Qianqian ZhaoJilie Kong
Apr 30, 2017·Chemical Science·Zhichao DaiJingli Yuan
Dec 17, 2016·Chemical Communications : Chem Comm·J K MolloyF Thomas
Mar 10, 2016·The Analyst·Saisai LiuSuhua Wang
Jun 15, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Qiang ZhaoXian-He Bu
Dec 12, 2017·ChemistryOpen·Felix FaschingerHermann J Gruber
Dec 12, 2019·Chemical Communications : Chem Comm·Richard BarréFabrice Thomas
Mar 30, 2018·Mikrochimica Acta·Jie GaoHongliang Tan
Apr 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangli LiuJingli Yuan
May 8, 2013·Angewandte Chemie·Kohei MiyataYasuchika Hasegawa
Aug 6, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Chaohao WenYuhui Zheng
Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena Del Giorgio, Thomas Just Sørensen
Feb 17, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Pooja JoshiVimal K Bhardwaj
Apr 4, 2021·The FEBS Journal·Chantal GalaupFabrice Collin
Nov 6, 2013·Analytical Chemistry·Zhichao DaiJingli Yuan
Jun 6, 2014·Inorganic Chemistry·Katie L PetersonValérie C Pierre
Nov 30, 2012·Analytical Chemistry·Yunna XiaoJingli Yuan
Feb 3, 2018·Chemical Reviews·Kenneth Yin ZhangWei Huang
Nov 13, 2014·Analytical Chemistry·Zhichao DaiJingli Yuan
Sep 11, 2019·Inorganic Chemistry·Katherine R Johnson, Ana de Bettencourt-Dias
Sep 3, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Meltem AlpFatih Algi