PMID: 16503869Mar 1, 2006Paper

A rationale for combined therapy with a calcium channel blocker and a statin: evaluation of basic and clinical evidence

Current Drug Targets. Cardiovascular & Haematological Disorders
R Preston Mason

Abstract

Calcium channel blockers and HMG-CoA reductase inhibitors are widely used for the management of hypertension and dyslipidemia, respectively. The use of these agents in the prevention and treatment of cardiovascular disease remains largely based on their actions in lowering blood pressure and lipids. Recent clinical trials, however, indicate that certain members of these two drug classes may slow progression of disease to an extent that cannot be solely attributed to risk factor reduction. The proposed mechanisms for such pleiotropic actions include enhancement of endothelial-dependent nitric oxide bioavailability, anti-inflammatory activity, and inhibition of oxidative stress. To understand the basis for such effects, along with potential synergies, we will review the basic and clinical evidence that indicate a broader opportunity for treatment and protection of cardiovascular events by atheroprotection with these agents beyond risk factor management.

Citations

Nov 1, 2011·Current Atherosclerosis Reports·Roderick Deano, Matthew Sorrentino
May 30, 2009·Vascular Health and Risk Management·Madhuri Devabhaktuni, Sripal Bangalore
Aug 11, 2010·Behavioural Brain Research·Harikesh KaloniaAnil Kumar
Nov 13, 2012·Expert Opinion on Pharmacotherapy·Antonia Delgado-Montero, Jose L Zamorano
Jun 19, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Chong-Ki LeeJoon Seok Bang
Oct 18, 2007·Biopharmaceutics & Drug Disposition·Dong-Hyun ChoiHyo-Kyung Han
Feb 29, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kate McKeage, M Asif A Siddiqui

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