PMID: 11332526May 3, 2001Paper

A re-analysis of a caries clinical trial by survival analysis

Journal of Dental Research
A HanniganA J Roberts

Abstract

The decline in caries prevalence, the increases in the level of fluoride exposure, and the lack of placebo control subjects have complicated caries clinical trials in recent times. There has been a substantial increase in the numbers of subjects required for the detection of statistically significant differences between dental products, and hence, the cost of these trials has grown enormously. This study uses a new statistical approach to the analysis of the data from these trials with the ultimate aim of providing a more sensitive method of analysis. The new approach uses survival analysis, where the outcome measure is the survival time of an individual tooth surface. It exploits recent developments in the analysis of clustered survival data where survival times within the same cluster or subject are correlated. To illustrate, the new method of analysis was used for the North Wales, UK, caries clinical trial. It is concluded that survival analysis uses most of the data available in a caries clinical trial, an outcome measure that is easily understood and may lead to a more sensitive method of analysis.

References

Jan 1, 1992·Caries Research·R K ChestersK W Stephen
Jun 1, 1990·Journal of Periodontology·P P HujoelT A DeRouen
Feb 1, 1994·Journal of Dental Research·P P HujoelK K Mäkinen
Nov 1, 1995·Journal of Dental Research·T A DeRouenL A Mancl
Feb 1, 1997·Community Dentistry and Oral Epidemiology·J D BeckG G Koch
Apr 25, 2000·Caries Research·A HanniganA J Roberts

❮ Previous
Next ❯

Citations

Dec 13, 2006·Journal of Dentistry·Kaja LeskinenMarkku Larmas
Nov 18, 2014·Community Dentistry and Oral Epidemiology·Hyo-Jin LeeKwang-Hak Bae
Mar 6, 2013·Journal of Dentistry·Ailish Hannigan, Christopher D Lynch
Aug 20, 2005·Journal of Dental Research·M C M WongE C M Lo
Aug 3, 2004·Journal of Dental Research·J W Stamm
Aug 3, 2004·Journal of Dental Research·L A ManclT A DeRouen
Aug 3, 2004·Journal of Dental Research·A Hannigan
Sep 22, 2018·Journal of Public Health Dentistry·Tariq S GhazalJustine L Kolker
Aug 30, 2008·The Journal of Infectious Diseases·Michael P BuschSally Caglioti
Jul 9, 2003·Community Dentistry and Oral Epidemiology·Vibeke BaelumMichael Vaeth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.