A re-examination of the possibility of controlling the firing rate gain of neurons by balancing excitatory and inhibitory conductances

Experimental Brain Research
C Capaday

Abstract

It has been suggested that balancing excitatory and inhibitory conductance levels can control the firing rate gain of single neurons, defined as the slope of the relation between discharge frequency and excitatory conductance. According to this view the increase in firing rate produced by an input pathway can be controlled independently of the ongoing firing rate by adjusting the mixture of excitatory and inhibitory conductances produced by other pathways converging onto the neuron. These conclusions were derived from a simple RC-neuron model with no active conductances, or firing threshold mechanism. The analysis of that model considered only the subthreshold behaviour and did not consider the relation between total trans-membrane conductance and firing rate. Similar conclusions were also derived from a simple parallel conductance based model. In this paper I consider, as an example of a repetitively firing neuron, a generic model of cat lumbar alpha-motoneurons with excitatory and inhibitory inputs and a second independent excitatory pathway. The excitatory and inhibitory inputs can be thought of as central descending controls while the second excitatory pathway may represent, for example, the monosynaptic Ia-afferent pathway...Continue Reading

Citations

Jun 25, 2002·Trends in Neurosciences·Charles Capaday
Jun 20, 2006·Journal of Integrative Neuroscience·Charles Capaday, Carl van Vreeswijk
Sep 15, 2005·Neural Computation·Claude Meunier, Karol Borejsza
Jun 8, 2014·The Journal of Physiology·Ben D B WillmoreAndrew J King
Nov 14, 2006·Computers in Biology and Medicine·M F Vieira, A F Kohn
May 14, 2003·Neuron·Simon J Mitchell, R Angus Silver
Jun 10, 2010·Nature Reviews. Neuroscience·R Angus Silver
Nov 1, 2013·Journal of Neurophysiology·Josef LadenbauerKlaus Obermayer

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