A reactive oxygen species-mediated component in neurogenic vasodilatation.

Cardiovascular Research
Anna StarrSusan D Brain

Abstract

Activation of the transient receptor potential vanilloid receptor 1 (TRPV1) leads to release of potent microvascular vasodilator neuropeptides. This study was designed to investigate in vivo mechanisms involved in TRPV1-mediated peripheral vasodilatation. Wildtype (WT) and TRPV1 knockout (KO) mice were investigated in a model of peripheral vasodilatation. Blood flow was measured by laser Doppler flowmetry under anaesthesia and following local application of the TRPV1 agonist capsaicin. A sustained (60 min) increase in blood flow was observed in WT but not TRPV1 KO mouse ears. This response was resistant to blockers of classic vasodilators but inhibited in pharmacogenetic experiments that targeted blockade of the substance P (SP) and calcitonin gene-related peptide (CGRP) pathways. The TRPV1-mediated vasodilatation was also attenuated by treatment with superoxide dismutase and the hydrogen peroxide scavenger catalase, but not by deactivated enzymes, supporting a novel role for reactive oxygen species (ROS) generation. Furthermore, neurogenic vasodilatation was observed neither in the presence of the selective NADPH inhibitor apocynin, nor in gp91 phox KO mice, under conditions where prostaglandin E1-induced vasodilatation occurr...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Jul 1, 1991·British Medical Bulletin·H P RangA Dray
Jan 3, 1985·Nature·S D BrainI MacIntyre
Sep 1, 1993·Circulation Research·S GulbenkianL Edvinsson
Sep 20, 1996·Science·C R BozicN P Gerard
Apr 20, 1999·Neuroreport·A M SalmonJ P Changeux
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·P CesareP A McNaughton
Mar 11, 2000·British Journal of Pharmacology·H DoodsW Eberlein
Jan 30, 2002·British Journal of Pharmacology·Andrew D GrantSusan D Brain
Mar 29, 2003·Cephalalgia : an International Journal of Headache·H-C Diener, UNKNOWN RPR100893 Study Group
Oct 15, 2003·Hypertension·Kosuke InokuchiAkira Takeshita
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark S KramerYih Lee
Mar 12, 2004·The New England Journal of Medicine·Jes OlesenUNKNOWN BIBN 4096 BS Clinical Proof of Concept Study Group
Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hiroaki Shimokawa, Tetsuya Matoba
Jul 23, 2004·Physiological Reviews·Susan D Brain, Andrew D Grant
Aug 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Laibaik ParkCostantino Iadecola
Oct 12, 2004·Journal of Cardiovascular Pharmacology·Gabriele FragassoAlberto Margonato
Feb 18, 2005·Acta Pharmacologica Sinica·Donna H Wang
Jun 7, 2005·Life Sciences·Luciano De Petrocellis, Vincenzo Di Marzo
Jun 21, 2005·Experimental Neurology·H H KrämerF Birklein
Aug 18, 2005·Clinical Science·Robin Ray, Ajay M Shah
Oct 8, 2005·Circulation Research·Alyson A MillerChristopher G Sobey
Apr 18, 2006·Pharmacology & Therapeutics·Alyson A MillerChristopher G Sobey
Jul 17, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shruti SharmaStephen M Black

❮ Previous
Next ❯

Citations

Dec 25, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Petra HartmannAndrea Szabó
Aug 31, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ravi Goyal, Lawrence D Longo
Jan 6, 2011·The Journal of Pharmacology and Experimental Therapeutics·Rabea GraepelSusan D Brain
Oct 31, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anaya MitraNeil E Rowland
Jul 3, 2013·International Journal of Inflammation·Kate Marie LewisRobert Vink
Nov 15, 2011·The Journal of Investigative Dermatology. Symposium Proceedings·Aisah A Aubdool, Susan D Brain
Feb 1, 2011·Free Radical Biology & Medicine·Daniela SalveminiWilliam L Neumann
Mar 5, 2011·Pain Practice : the Official Journal of World Institute of Pain·Eric J Visser
Nov 14, 2012·British Journal of Pharmacology·Jennifer Victoria Bodkin, Elizabeth Soares Fernandes
Sep 23, 2014·Mediators of Inflammation·Elizabeth S FernandesMarcos A G Grisotto
Dec 14, 2011·Physiology & Behavior·Richard E HartmanLawrence D Longo
Mar 31, 2015·BioMed Research International·Munvar Miya Shaik, Siew Hua Gan
Jun 3, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Éva BorbélyZsuzsanna Helyes
Dec 17, 2014·Nature Communications·Aisah A AubdoolSusan D Brain
Nov 15, 2012·Hypertension·Nichola J MarshallSusan D Brain
May 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Giacinta GuariniIan N Bratz
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth S FernandesSusan D Brain
Jul 27, 2020·Translational Animal Science·Rayana Brito da SilvaRenata Apocalypse Nogueira Pereira
Jun 22, 2019·Oxidative Medicine and Cellular Longevity·Domingos Magno Santos PereiraElizabeth Soares Fernandes
Dec 8, 2017·BioMed Research International·Yohannes W WoldeamanuelRobert P Cowan
Jun 24, 2020·European Journal of Pharmacology·Fatemeh GharishvandiAhmad Reza Dehpour
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Boris LavanderosOscar Cerda
May 2, 2018·The Journal of Pain : Official Journal of the American Pain Society·Tian-Zhi GuoJohn David Clark
Jan 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beihua ZhongDonna H Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.