A reactor-like spinneret used in 3D printing alginate hollow fiber: a numerical study of morphological evolution

Soft Matter
Y LiQingxi Hu

Abstract

In this paper, a reactor-like spinneret is proposed to generate a continuous hollow hydrogel fiber. In order to reliably control the deforming dynamics, the components of the spinneret are standardized in order to ease the online observation of morphological evolution. We found that not only did a co-flow occur in the tubular space, but a relatively large shrinkage of the shell layer at the outlet also occurred. Whereupon a weak coupling of the velocity field and diffusion-reacting co-flow was developed to describe the monitored co-flow morphology and to simulate the intermediate state of the concentration field, as well as to calculate the shrinkage profile with an integral formula. And a critical isogram [G]cri was determined to correspond to the morphological segmental feature, to trigger gelation and shrinkage as a threshold of solubility and the integral upper limit of the shrinkage region. Experimental evidence indicates that: the simulation is able to effectively predict the inner diameter of the hollow fiber; the transient inner diameter of the fiber at the outlet is expanded by approximately 70 μm (co-flow distance = 15 mm) as compared to the initial fluid dynamics value, and that the relative mean error of the simulat...Continue Reading

References

Sep 1, 2007·Journal of Cellular and Molecular Medicine·D W Hutmacher, S Cool
Oct 13, 2007·Physical Review Letters·Andrew S UtadaDavid A Weitz
Nov 3, 2009·Biomaterials·Min HuJackie Y Ying
Mar 1, 2011·Analytical Chemistry·Thomas BraschlerPhilippe Renaud
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Mar 6, 2013·Biofabrication·Yahui ZhangIbrahim T Ozbolat
Jan 13, 2015·Biomaterials Science·Yahui ZhangIbrahim T Ozbolat
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cristina ColosiMariella Dentini

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Citations

Nov 6, 2018·Biomechanics and Modeling in Mechanobiology·Yu LiPingyan Bian
Sep 7, 2019·Chemical Communications : Chem Comm·Qing ChenLidong Zhang

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