A real-time documentation and mechanistic investigation of quantum dots-induced autophagy in live Caenorhabditis elegans

Biomaterials
Yanfeng ZhouYao He

Abstract

Autophagy is a highly important intracellular process for the degradation of endogenous or foreign contents in the cytoplasm. Though nanomaterials-induced autophagy has been extensively studied, real-time information about the autophagic process induced by nanomaterials in live organisms remains unknown. Here by using Caenorhabditis elegans as the model organism and fluorescent semiconductor quantum dots (QDs) as a representative nanomaterial, we systematically investigated the phenomenon of QDs-induced autophagy in live organisms. Our results demonstrated that the internalized QDs trigger a complete autophagic process in C. elegans intestinal cells. Further investigations revealed that this QD-induced autophagy in C. elegans is neither a response to released heavy metal ions by the QDs, nor an attempt to engulf exogenous QD materials, but a defensive strategy of the organism to clear and recycle damaged endosomes. Of particular significance, for the first time, we presented real-time tracking of autophagosomes formation in live organisms, providing detailed temporal-spatial information of this process. This study may help us better understand the relationship between nanomaterials and autophagy in vivo, and provide invaluable ...Continue Reading

References

Sep 25, 1998·Science·M BruchezA P Alivisatos
Dec 2, 2000·Science·D J Klionsky, S D Emr
Aug 6, 2002·Science·Ray H BaughmanWalt A de Heer
Aug 7, 2004·Developmental Cell·Ryan C ScottThomas P Neufeld
Jun 2, 2005·Nature Materials·Igor L MedintzHedi Mattoussi
Feb 4, 2006·Science·Andre NelNing Li
Dec 14, 2006·Nano Letters·Oleksandr SeleverstovAugustinus Bader
Feb 6, 2007·Angewandte Chemie·An-Hui LuFerdi Schüth
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Sung Ju ChoFrançoise M Winnik
Mar 14, 2007·Autophagy·Olga ZabirnykOleksandr Seleverstov
May 30, 2008·Molecular Biology of the Cell·Zhiping XieDaniel J Klionsky
Oct 14, 2008·Cellular and Molecular Life Sciences : CMLS·S H WangC M Shih
May 30, 2009·Accounts of Chemical Research·Jinhao GaoBing Xu
May 15, 2010·Biomaterials·Jasmine J LiLin-Yue L Yung
Feb 4, 2011·Journal of the American Chemical Society·Marco P MonopoliKenneth A Dawson
Jul 20, 2011·Toxicology and Applied Pharmacology·Young-Ok SonXianglin Shi
May 23, 2012·Nano Letters·Elena ZanniDaniela Uccelletti
Jul 17, 2012·Biomaterials·Zoran M MarkovicVladimir S Trajkovic
Oct 5, 2012·ACS Nano·Giorgia BrancoliniStefano Corni
Dec 18, 2012·Environmental Science & Technology·Elizabeth Q ContrerasVicki L Colvin
Mar 29, 2013·Nanotechnology·Wei ZhouLongping Wen
Apr 30, 2013·Biomaterials·Po-Hsuan ChenCheng-Chung Chou
Jul 23, 2013·Free Radical Biology & Medicine·Xin WenYuquan Wei

❮ Previous
Next ❯

Citations

Oct 18, 2016·Environment International·Thiago Lopes RochaMaria João Bebianno
Jan 1, 2019·Advanced Biosystems·Fujing Wei, Yixiang Duan
Jun 3, 2021·Environmental Toxicology and Chemistry·Yimeng LiTianshu Wu
Jan 14, 2019·ACS Biomaterials Science & Engineering·Koushik DebnathNikhil R Jana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.