A Real-world Analysis of Treatment Patterns for Cholinesterase Inhibitors and Memantine among Newly-diagnosed Alzheimer's Disease Patients

Neurology and Therapy
Nawal Bent-EnnakhilHoward Fillit

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative form of dementia. Pharmacological therapies for symptomatic treatment, such as acetylcholinesterase inhibitors (AChEIs) and memantine, have been available in the USA since 2000. Over the past decade, few studies have analyzed real-world anti-dementia treatment patterns in the USA. This study evaluated monotherapy AChEIs and memantine treatment patterns among newly diagnosed AD patients. A retrospective cohort study was conducted using Medicare data and the Minimum Data Set from 2008 to 2012. Patients aged 65-100 years with newly diagnosed AD (ICD-9 code: 331.0) and monotherapy AChEI or memantine treatment initiated after diagnosis were included. Descriptive treatment pattern analyses, including discontinuation and switch, were undertaken. Kaplan-Meier curves were developed to examine the treatment duration. A total of 9812 newly diagnosed AD patients were identified, with 56.7% (n = 5567) first receiving anti-dementia treatment after the initial AD diagnosis. Among patients initiating monotherapy AChEIs or memantine after AD diagnosis (N = 5200), 51.6% continued index treatment during the entire follow-up period (mean follow-up: 659.7 days) and 21.7% discontinued tre...Continue Reading

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Jul 25, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Sandipan BhattacharjeeWilliam J Burke
Oct 22, 2019·Alzheimer Disease and Associated Disorders·Gary P StoehrMary Ganguli
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Aug 24, 2021·Journal of Alzheimer's Disease : JAD·Zaina P QureshiRezaul Khandker
Sep 29, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jeffrey L CummingsEric Ponton

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Methods Mentioned

BETA
pharmacotherapy
MDS

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