A Real-World Study on Antidepressant-Associated Sexual Dysfunction in 2144 Outpatients: The SALSEX I Study

Archives of Sexual Behavior
Angel L MontejoSALSEX Working Study Group

Abstract

The objective of this cross-sectional study was to evaluate the frequency, impact, and management of sexual dysfunction associated with commonly prescribed antidepressants available in psychiatry outpatient clinics in Spain. We recruited 2163 adult patients who had undergone treatment with antidepressants for at least 8 weeks and had a history of normal sexual functioning before the prescription of the antidepressant, except for mildly impaired libido. We used the Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX) for evaluating the frequency and tolerance of sexual dysfunction and whether this side effect was spontaneously reported. Overall, 79% patients showed sexual dysfunction, as indicated by a total score ≥ 3 on the PRSexDQ-SALSEX; 64% showed moderate-severe sexual dysfunction, with no differences between men and women on these outcomes. In the multivariate logistic regression analysis, treatment with a serotonergic antidepressant and having a severe clinical state of psychiatric illness were the factors associated with the highest likelihood of presenting with sexual dysfunction. Sexual dysfunction was spontaneously reported by 838 (41%) of the 2066 evaluable patients for this outcome. Among patients ...Continue Reading

References

Feb 18, 1999·JAMA : the Journal of the American Medical Association·E O LaumannR C Rosen
May 10, 2002·The Journal of Clinical Psychiatry·Anita H ClaytonAlan Metz
May 13, 2003·Current Medical Research and Opinion·Mireille BonierbaleJean Tignol
Jun 25, 2004·International Journal of Impotence Research·E O LaumannUNKNOWN GSSAB Investigators' Group
Nov 10, 2004·Urology·Alfredo NicolosiUNKNOWN Global Study of Sexual Attitudes and Behaviors Investigators' Group
Jul 27, 2006·Journal of Psychiatric and Mental Health Nursing·A HigginsC M Begley
Feb 6, 2007·Lancet·Rosemary Basson, Willibrord Weijmar Schultz
May 15, 2009·Journal of Clinical Psychopharmacology·Alessandro Serretti, Alberto Chiesa
Jan 23, 2010·The Journal of Sexual Medicine·Rosemary BassonLuca Incrocci
Apr 17, 2010·Psychiatry Investigation·Kyoung-Uk LeeTae-Youn Jun
Jan 5, 2011·International Journal of Mental Health Nursing·Chris QuinnGraeme Browne
Feb 24, 2011·Issues in Mental Health Nursing·Chris QuinnGraeme Browne
Nov 22, 2011·Human Psychopharmacology·Angel MontejoSidney H Kennedy
Nov 30, 2011·International Journal of Psychiatry in Clinical Practice·Héctor DueñasJoel Raskin
Dec 18, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ursula ReichenpfaderBradley N Gaynes
Apr 2, 2014·Postgraduate Medicine·Anita H ClaytonLata Handiwala
Aug 26, 2014·Expert Opinion on Drug Safety·Anita H ClaytonAlexandra Elizabeth Schuck
Oct 23, 2014·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Nicholas A KeksChristine Culhane
Sep 19, 2015·Current Opinion in Psychiatry·Angel L MontejoFelipe Navarro-Cremades
Nov 1, 2015·CNS Drugs·David S BaldwinMagda Nowak
Aug 16, 2016·The Psychiatric Clinics of North America·Anita H ClaytonJennifer G Votta
Aug 6, 2017·Sexual Medicine Reviews·Areeg BalaWayne J G Hellstrom
Jan 21, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Angel L MontejoDavid S Baldwin

❮ Previous
Next ❯

Citations

Jun 28, 2019·Journal of Clinical Medicine·Nerea M Casado-EspadaÁngel L Montejo
Nov 14, 2019·Journal of Clinical Medicine·Angel L Montejo
Oct 1, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Yun DuMiao Qu
Oct 9, 2019·Journal of Clinical Medicine·Angel L MontejoLaura Montejo
Jul 7, 2020·Frontiers in Neuroscience·Angel L Montejo, Mario Lourenço
May 24, 2019·Journal of Clinical Medicine·Angel L MontejoJosé L Villegas
Oct 23, 2020·Perspectives in Psychiatric Care·Alev Ekemen, Kerime Derya Beydağ

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Psychiatry
R M Hirschfeld
The Journal of Gender-specific Medicine : JGSM : the Official Journal of the Partnership for Women's Health at Columbia
B BartlikA J Gelenberg
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Piotr GałeckiMonika Talarowska
Expert Review of Neurotherapeutics
Thomas M KesslerJalesh N Panicker
© 2022 Meta ULC. All rights reserved