A realistic validation study of a new nitrogen multiple-breath washout system.

PloS One
Florian SingerPer Gustafsson

Abstract

For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be realistically validated. We describe a new lung model for in vitro validation under physiological conditions and the assessment of a new nitrogen (N(2))MBW system. The N(2)MBW setup indirectly measures the N(2) fraction (F(N2)) from main-stream carbon dioxide (CO(2)) and side-stream oxygen (O(2)) signals: F(N2) = 1-F(O2)-F(CO2)-F(Argon). For in vitro N(2)MBW, a double chamber plastic lung model was filled with water, heated to 37°C, and ventilated at various lung volumes, respiratory rates, and F(CO2). In vivo N(2)MBW was undertaken in triplets on two occasions in 30 healthy adults. Primary N(2)MBW outcome was functional residual capacity (FRC). We assessed in vitro error (√[difference](2)) between measured and model FRC (100-4174 mL), and error between tests of in vivo FRC, lung clearance index (LCI), and normalized phase III slope indices (S(acin) and S(cond)). The model generated 145 FRCs under BTPS conditions and various breathing patterns. Mean (SD) error was 2.3 (1.7)%. In 500 to 4174 mL FRCs, 121 (98%) of FRCs were within 5%. In 100 to 400 mL FRCs, the error was better than 7%. In vivo FRC error between tests was 10.1 (8...Continue Reading

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Citations

Jun 8, 2013·American Journal of Respiratory and Critical Care Medicine·Padmaja SubbaraoFelix Ratjen
Aug 21, 2013·American Journal of Respiratory and Critical Care Medicine·Nicole Beydon, Paul D Robinson
Aug 6, 2014·Paediatric Respiratory Reviews·Paul D Robinson
Jul 25, 2014·Pediatric Pulmonology·Anja BiglerPhilipp Latzin
Oct 5, 2013·Chest·Florian SingerPhilipp Latzin
Sep 12, 2015·American Journal of Respiratory and Critical Care Medicine·Kathryn A RamseyUNKNOWN AREST CF
Jun 25, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Chiara AbbasPhilipp Latzin
Jun 21, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kathryn A Ramsey, Sarath Ranganathan
Jul 16, 2013·Pediatric Pulmonology·Florian SingerPhilipp Latzin
Dec 10, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·L KentUNKNOWN European Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN) Standardisation Committee
Oct 1, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sophie YamminePhilipp Latzin
Sep 30, 2015·Pediatric Pulmonology·Cindy ThamrinPaul D Robinson
Feb 28, 2014·Pediatric Pulmonology·Anne SchmidtFlorian Singer
Jan 24, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·A PflegerE Eber
Jul 15, 2015·PloS One·Selina SummermatterSophie Yammine
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Jul 7, 2017·Pediatric Pulmonology·Tim RosenowUNKNOWN AREST CF
Apr 28, 2016·Inflammatory Bowel Diseases·Sophie YammineChristiane Sokollik
Mar 25, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sylvia NyilasManuela Funke
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Jan 24, 2018·Journal of Applied Physiology·Jason H T Bates, Ubong Peters
May 22, 2020·Pediatric Pulmonology·Sarah M IsaacFelix Ratjen
Aug 28, 2020·Physiological Reports·Per M GustafssonPaul D Robinson

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