A reappraisal of serial isotope bone scans in prostate cancer

The British Journal of Radiology
J M O'DonoghueH F Given

Abstract

Carcinoma of the prostate is the commonest malignancy of the genitourinary tract in the male and is frequently associated with metastatic bone disease. Serial isotope bone scans for screening secondary deposits are not cost-effective. We have evaluated the serum prostate markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) as an alternative to conventional serial bone scanning in 129 patients with newly diagnosed prostate cancer over a period of 3 years. Although serum PSA did not reflect local tumour burden at presentation, it was significantly elevated in those who presented with stage D disease (p < 0.01). 45 patients presented de novo with metastatic bone deposits and a further 18 patients developed metastases during the study period. The sensitivity of PSA in detecting secondary deposits at presentation for levels in excess of 100 micrograms/l was 93.75%, the positive predictive value 95.7% and the negative predictive value for levels less than 5 micrograms/l was 90.6%. During the follow-up period the sensitivity was 94.4%, the positive predictive value 100% and the negative predictive value 100%, with a median lead time of 3 months in predicting metastases in the 18 patients with progressive diseas...Continue Reading

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Citations

Apr 1, 1995·Seminars in Nuclear Medicine·P J Ryan, I Fogelman
May 1, 1997·The Urologic Clinics of North America·C T Lee, J E Oesterling
Jun 3, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·M A Díaz-MartínE G De La Peña
Apr 1, 1997·Seminars in Nuclear Medicine·A Z KrasnowA T Isitman

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