A recent bottleneck of Y chromosome diversity coincides with a global change in culture.

Genome Research
Monika KarminToomas Kivisild

Abstract

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

References

May 1, 1997·Genetics·M C Whitlock, N H Barton
Apr 29, 1998·Molecular Biology and Evolution·M F HammerS L Zegura
Feb 6, 2002·Genome Research·UNKNOWN Y Chromosome Consortium
Feb 21, 2003·Nature·James M BowlerNigel A Spooner
Aug 5, 2003·Nature Reviews. Genetics·Mark A Jobling, Chris Tyler-Smith
Dec 24, 2003·American Journal of Human Genetics·Lev A ZhivotovskyLuba Kalaydjieva
Jun 11, 2004·Molecular Biology and Evolution·Giovanni Destro-BisolCristian Capelli
Dec 2, 2004·Bioinformatics·Kai M A Chan, Brian R Moore
Mar 31, 2005·Trends in Genetics : TIG·Evelyne HeyerFrédéric Austerlitz
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Feb 12, 2010·Nature·Morten RasmussenEske Willerslev
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christopher R GignouxJoanna L Mountain
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Aug 1, 2012·Nature Methods·Diego DarribaDavid Posada
Oct 6, 2012·Genome Research·Wei WeiChris Tyler-Smith
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paul MellarsMartin B Richards
Oct 3, 2013·Nature Communications·Stephen ShennanMark G Thomas
Oct 30, 2013·Human Mutation·Mannis van OvenMaarten H D Larmuseau
Apr 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hugo Reyes-CentenoKaterina Harvati
Jun 24, 2014·Nature Genetics·Stephan Schiffels, Richard Durbin
Dec 3, 2014·American Journal of Human Genetics·Florian J ClementeToomas Kivisild
Dec 4, 2014·Molecular Biology and Evolution·Pille HallastMark A Jobling
Jan 1, 2015·Investigative Genetics·Antti Sajantila

❮ Previous
Next ❯

Citations

Jan 13, 2016·Genome Biology·Marc HaberChris Tyler-Smith
Dec 23, 2015·American Journal of Physical Anthropology·Viktor ČernýConnie J Mulligan
Apr 5, 2016·Human Genetics·Chiara BarbieriBrigitte Pakendorf
Apr 9, 2016·American Journal of Human Genetics·Fernando L MendezCarlos D Bustamante
Jun 10, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jelena ŠaracPavao Rudan
Jun 28, 2016·Scientific Reports·Beniamino TrombettaFulvio Cruciani
Jul 9, 2016·American Journal of Human Genetics·Anne-Mai IlumäeSiiri Rootsi
Jul 21, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Irina MorozovaTatiana V Tatarinova
Sep 7, 2016·Current Opinion in Genetics & Development·Timothy H Webster, Melissa A Wilson Sayres
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Christopher R von Rueden, Adrian V Jaeggi
Oct 7, 2016·Current Opinion in Genetics & Development·Feng Gao, Alon Keinan
Dec 29, 2016·European Journal of Human Genetics : EJHG·Maïté RivollatPascale Gerbault
Jan 26, 2017·European Journal of Human Genetics : EJHG·Pierpaolo Maisano DelserMark A Jobling
Mar 18, 2017·Human Genetics·Beniamino Trombetta, Fulvio Cruciani
May 31, 2017·Nature Reviews. Genetics·Mark A Jobling, Chris Tyler-Smith
Oct 28, 2017·American Journal of Physical Anthropology·Aram YardumianTheodore G Schurr
Oct 30, 2015·Journal of Human Genetics·Neetu NegiKumarasamy Thangaraj
May 3, 2018·Genome Biology and Evolution·Danling YeKateryna D Makova
May 2, 2018·Annual Review of Genomics and Human Genetics·Pontus Skoglund, Iain Mathieson
Sep 1, 2018·Molecular Biology and Evolution·Leonardo AriasBrigitte Pakendorf
Jan 26, 2018·Scientific Reports·Wibhu KutananMark Stoneking
Feb 23, 2019·Molecular Ecology·Linnéa SmedsHans Ellegren
Apr 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Federico Sánchez-QuintoMattias Jakobsson
Apr 14, 2019·Molecular Biology and Evolution·Wibhu KutananMark Stoneking
Jun 12, 2019·Annals of Human Biology·Christiana L ScheibToomas Kivisild
Nov 28, 2018·Nature Communications·Thiseas C LamnidisStephan Schiffels
Dec 31, 2017·Molecular Genetics and Genomics : MGG·Yun-Zhi HuangHui Li
Mar 7, 2020·American Journal of Physical Anthropology·Nelson Rivera FrancoGuillermo Barreto

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Ancient DNA

Ancient DNA sequences are able to offer valuable insights into molecular evolutionary processes, but are notoriously difficult to analyze due to molecular damage and exogenous dna contamination. Discover the latest research on Ancient DNA here.