PMID: 8606165Apr 1, 1996Paper

A recent fixation of cfiA genes in a monophyletic cluster of Bacteroides fragilis is correlated with the presence of multiple insertion elements

Journal of Bacteriology
R RuimyE Collatz

Abstract

Small-subunit ribosomal DNA sequences of 16 strains of Bacteroides fragilis were determined and compared with previously published sequences. Three phylogenetic methods (the neighbor-joining, maximum-likelihood, and maximum-parsimony methods) as well as a bootstrap analysis were used to assess the robustness of each topology. All phylogenetic analyses demonstrated that the B. fragilis strains were clearly divided into two robust monophyletic units which corresponded to the cfiA-negative and cfiA-positive groups. Strains of two previously identified DNA homology groups separated similarly into the two monophyletic units. According to the intensity of the hybridization signal with a cfiA probe, the cfiA-positive cluster could be further divided into two groups. This difference might reflect the existence of two, probably closely related cfiA-type genes. In the strongly hybridizing cfiA-positive strains, the gene is capable of conferring high-level resistance to the carbapenems and to most beta-lactamase inhibitors as well, while in the weakly hybridizing cfiA-positive strains, only the latter type of resistance is known to occur. The presence of the cfiA-type genes within a monophyletic cluster of B. fragilis that apparently repr...Continue Reading

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Citations

Dec 13, 2005·The Journal of Antimicrobial Chemotherapy·József SókiBrian I Duerden
Jun 2, 2016·The Journal of Antimicrobial Chemotherapy·József SókiEdit Urbán
Sep 26, 2007·Journal of Medical Microbiology·Gabriella TerhesElisabeth Nagy
Oct 31, 2006·Applied and Environmental Microbiology·Simy L BuckwoldAugusto A Franco
Jun 13, 2001·Infection and Immunity·M J CoyneL E Comstock
Apr 15, 2009·Antimicrobial Agents and Chemotherapy·Nuria GarcíaAlberto Quesada
Nov 20, 2012·International Journal of Antimicrobial Agents·József SókiUNKNOWN ESCMID Study Group on Anaerobic Infections
Jul 11, 1998·Plasmid·C J SmithD P Bayley
Sep 1, 2021·Journal of Medical Microbiology·József SókiElisabeth Nagy
Apr 21, 2009·Diagnostic Microbiology and Infectious Disease·Kwan Soo KoYoon-Hoh Kook

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