A receptor for phosphatidylserine-specific clearance of apoptotic cells

Nature
Valerie A FadokPeter M Henson

Abstract

cytosis of cellular corpses. During apoptosis, the asymmetry of plasma membrane phospholipids is lost, which exposes phosphatidylserine externally. The phagocytosis of apoptotic cells can be inhibited stereospecifically by phosphatidylserine and its structural analogues, but not by other anionic phospholipids, suggesting that phosphatidylserine is specifically recognized. Using phage display, we have cloned a gene that appears to recognize phosphatidylserine on apoptotic cells. Here we show that this gene, when transfected into B and T lymphocytes, enables them to recognize and engulf apoptotic cells in a phosphatidylserine-specific manner. Flow cytometric analysis using a monoclonal antibody suggested that the protein is expressed on the surface of macrophages, fibroblasts and epithelial cells; this antibody, like phosphatidylserine liposomes, inhibited the phagocytosis of apoptotic cells and, in macrophages, induced an anti-inflammatory state. This candidate phosphatidylserine receptor is highly homologous to genes of unknown function in Caenorhabditis elegans and Drosophila melanogaster, suggesting that phosphatidylserine recognition on apoptotic cells during their removal by phagocytes is highly conserved throughout phylogeny.

References

Jul 7, 1995·The Journal of Biological Chemistry·A RigottiM Krieger
Nov 1, 1995·The Journal of Experimental Medicine·B VerhovenPatrick L Williamson
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·G R Sambrano, D Steinberg
Feb 24, 1997·Biochemical and Biophysical Research Communications·Yukihiko AramakiSeishi Tsuchiya
May 1, 1997·Molecular Biology of the Cell·D PradhanRobert A Schlegel
Jan 10, 1998·The Journal of Biological Chemistry·Krishnakumar BalasubramanianAlan J Schroit
Apr 21, 1998·Nature·Andrew DevittChristopher D Gregory
Jun 17, 1998·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T NagaseOsamu Ohara
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·K OkaT Masaki
Feb 20, 1999·The Journal of Biological Chemistry·Akiko ShiratsuchiYoshinobu Nakanishi
Dec 4, 2003·Apoptosis : an International Journal on Programmed Cell Death·S M van den EijndeC Vermeij-Keers

Citations

Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·U K Messmer, J Pfeilschifter
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoshihiro KomoharaMotohiro Takeya
Mar 15, 2008·Inflammatory Bowel Diseases·Corinna GeigerFlorian Lang
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Stephan R SchefferTim F Greten
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·F G Blankenberg, H W Strauss
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Vijay SharmaDavid Piwnica-Worms
Apr 5, 2002·Medicinal Research Reviews·J Middleton Boon, Bradley D Smith
Jun 16, 2001·Cell Biology International·M E Jones, L M Schwartz
Jul 26, 2002·International Journal of Hematology·F Jon GeskeValerie A Fadok
Jun 22, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wei ZhuSixiang Zou
Apr 20, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philipp A LangFlorian Lang
Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniela S KempeFlorian Lang
Jul 19, 2008·Archives of Toxicology·Hasan MahmudFlorian Lang
Oct 26, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Philipp A LangChristophe Duranton
Oct 5, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Olivier M NiemoellerFlorian Lang
Dec 21, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Ravi S KasinathanFlorian Lang
Dec 20, 2005·The Journal of Membrane Biology·Florian LangS M Huber
Mar 15, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Albert Flotats, Ignasi Carrió
Jun 7, 2007·European Journal of Nuclear Medicine and Molecular Imaging·S L WoltersLeo Hofstra
Feb 3, 2009·Annals of Hematology·Sergios GatidisFlorian Lang
Oct 13, 2006·Cancer Chemotherapy and Pharmacology·Wei-Ciao WuBu-Miin Huang
Aug 26, 2011·Seminars in Immunopathology·Olivier MorelFlorence Toti
Nov 20, 2012·Lung·Jai Prakash MuyalHarsh Bhardwaj
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Olivier M NiemoellerFlorian Lang
Dec 7, 2007·Pflügers Archiv : European journal of physiology·Jan P NicolayFlorian Lang
Feb 3, 2009·Pflügers Archiv : European journal of physiology·Daniela S KempeFlorian Lang
May 22, 2010·Pflügers Archiv : European journal of physiology·Elisabeth LangFlorian Lang
Apr 20, 2007·International Journal of Clinical Oncology·Takuji MogamiSajio Sumida
Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·Krishnakumar BalasubramanianAlan J Schroit
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·M IturraldeA Anel
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·B ZhangR G Fenton
Jan 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·J A Sánchez-AlcázarPlácido Navas
Nov 3, 2006·Apoptosis : an International Journal on Programmed Cell Death·Nancy López-AntónVerena M Dirsch
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Meng FuShigaku Ikeda
Sep 5, 2006·Apoptosis : an International Journal on Programmed Cell Death·Dmitri V KryskoP Vandenabeele
Mar 20, 2010·Apoptosis : an International Journal on Programmed Cell Death·Christopher D Gregory, John D Pound
Aug 11, 2011·Apoptosis : an International Journal on Programmed Cell Death·Sang Youn HwangE K Lee
Jul 18, 2012·Bulletin of Experimental Biology and Medicine·O A PatutinaV V Vlasov
Aug 31, 2006·Cell and Tissue Banking·Sajio Sumida
Dec 25, 2010·Journal of Clinical Immunology·Juan P CerlianiGabriel A Rabinovich
Jan 19, 2011·Clinical Reviews in Allergy & Immunology·Marco FolciCarlo Selmi
Dec 11, 2008·Immunologic Research·Adam D Kennedy, Frank R DeLeo
Mar 29, 2008·International Journal of Hematology·Akihito FujimiYoshiro Niitsu
Feb 28, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Albert Flotats, Ignasi Carrió
Apr 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ji ZhangJin-Lin Wang
May 29, 2004·Biochimica Et Biophysica Acta·Robert F A ZwaalEdouard M Bevers
Jun 28, 2005·Progress in Lipid Research·J E Vance, Rineke Steenbergen
Nov 20, 2003·Trends in Cell Biology·Cynthia Grimsley, K S Ravichandran
Apr 23, 2003·Archives of Biochemistry and Biophysics·G G BorisenkoValerian E Kagan
Sep 25, 2002·Biochemical and Biophysical Research Communications·Peter VanlandschootGeert Leroux-Roels
Apr 23, 2003·Experimental Cell Research·Olivier GasserJürg A Schifferli
Jun 20, 2002·Journal of Immunological Methods·Chris P M ReutelingspergerLeo Hofstra
May 10, 2003·Journal of Immunological Methods·Valérie S ZimmermannAngelo A Manfredi
Jun 12, 2003·Journal of Immunological Methods·Peter ThumannLars Jenne
Nov 14, 2002·Progress in Biophysics and Molecular Biology·Florian Wernig, Qingbo Xu
Sep 10, 2002·Molecular Immunology·C PastorelliM Benhamou
Mar 28, 2002·Pharmacology & Therapeutics·E W Sun, Y F Shi
Nov 9, 2000·Immunology Today·M F LopesG A DosReis
Dec 18, 2001·Trends in Biotechnology·Zhiping Weng, Charles DeLisi
Sep 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kentaro FurumotoToshikiro Kimura
Oct 16, 2003·Brain Research. Molecular Brain Research·Gary ChinProbal Banerjee
Jun 19, 2001·Experimental Gerontology·V P Skulachev
Jan 16, 2002·Current Opinion in Immunology·Leanne PeiserSiamon Gordon
Jan 16, 2002·Current Opinion in Immunology·Steven Greenberg, Sergio Grinstein
Dec 11, 2002·Current Opinion in Cell Biology·Ronald J Krieser, Kristin White
Dec 5, 2000·Current Opinion in Biotechnology·S Sidhu
Sep 12, 2001·Current Opinion in Biotechnology·J Pelletier, S Sidhu
Feb 13, 2001·Trends in Biochemical Sciences·P M Clissold, C P Ponting
Dec 1, 2001·Immunity·A MacKenzieAnnmarie Surprenant
Jul 26, 2002·Seminars in Cell & Developmental Biology·Anant K Menon
Jan 5, 2002·Microbes and Infection·L A Knodler, B B Finlay
Jan 18, 2003·Biochimica Et Biophysica Acta·Patrick L Williamson, Robert A Schlegel
Jan 18, 2003·Biochimica Et Biophysica Acta·Y HamonGiovanna Chimini
Jun 20, 2002·Trends in Immunology·A Neil BarclayMarion H Brown
Mar 5, 2003·Trends in Immunology·Alma J NautaAnja Roos
Aug 28, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Walter H Dzik
Jan 4, 2008·Neuron Glia Biology·Mary A Logan, Marc R Freeman
Mar 2, 2012·Neuron Glia Biology·José Luis Marín-TevaJulio Navascués
May 21, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Ann E OliverAtul N Parikh
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·Peter M HensonValerie A Fadok
May 10, 2002·Nature·Rikinari HanayamaShigekazu Nagata
Jun 1, 2001·Nature Biotechnology·N P Restifo
Mar 29, 2008·Cell Death and Differentiation·María Angeles MellénPatricia Boya
May 3, 2008·Cell Death and Differentiation·Raymond B Birge, David S Ucker
Apr 17, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ayman El-Sayed, Hideyoshi Harashima
Jul 19, 2005·Nature Cell Biology·James I ElliottChristopher F Higgins
Dec 22, 2005·Nature Immunology·Charles N Serhan, John Savill
Jan 11, 2008·Nature Reviews. Cancer·Eduardo Moreno
Jan 19, 2008·Nature Reviews. Cancer·Anthony Letai
Nov 27, 2007·Nature Reviews. Immunology·K S Ravichandran, Ulrike Lorenz
Mar 22, 2002·Nature Reviews. Immunology·Leonid Gorelik, Richard A Flavell
Mar 2, 2005·Nature Reviews. Molecular Cell Biology·Joost C M Holthuis, Tim P Levine
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·Will Wood, Antonio Jacinto
Dec 13, 2007·Nature Reviews. Molecular Cell Biology·Rebecca C TaylorSeamus J Martin
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·E H Baehrecke
Apr 18, 2003·Cell Death and Differentiation·Andrew DevittChristopher D Gregory
Apr 18, 2003·Cell Death and Differentiation·C TurnerChristopher D Gregory
Mar 5, 2005·Cell Death and Differentiation·Philipp A LangStephan M Huber
Jun 18, 2005·Cell Death and Differentiation·F KleinclaussPhilippe Saas
Dec 13, 2005·Cell Death and Differentiation·Bengt Fadeel, Ding Xue
Jan 6, 2007·Cell Death and Differentiation·H ZhangC Tse
Mar 17, 2007·Cell Death and Differentiation·Goran PetrovskiLászló Fésüs
Jun 16, 2007·Cell Death and Differentiation·L-P Erwig, Peter M Henson
Oct 27, 2007·Cell Death and Differentiation·S-Y ParkI-S Kim
Oct 14, 2000·Cell Research·C Y Lee, E H Baehrecke
Feb 14, 2006·Cell Research·Elaine Y ChungXiaojing Ma
Dec 19, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael A ChattergoonDavid B Weiner
Jul 17, 2001·Clinical Endocrinology·J D Bretz, J R Baker
Jan 10, 2003·The New England Journal of Medicine·R S Hotchkiss, I E Karl
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael FöllerRobert Feil
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kit WongWenjun Ouyang
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jes-Niels BoeckelStefanie Dimmeler
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xia HongGongyi Zhang
Feb 22, 2012·Molecular & Cellular Proteomics : MCP·Giuseppe PalmisanoMartin Røssel Larsen
Oct 27, 2004·The Journal of Experimental Medicine·Attilio BondanzaMartin Herrmann
Aug 11, 2004·The Journal of Experimental Medicine·Kenichi AsanoMasato Tanaka
Jan 23, 2003·Cancer Biotherapy & Radiopharmaceuticals·Xueshu ZhangJim Xiang
Mar 29, 2001·Journal of Hematotherapy & Stem Cell Research·L HegyiJ N Skepper
Aug 17, 2006·Antioxidants & Redox Signaling·Florian LangThomas Wieder
Jun 30, 2007·Antioxidants & Redox Signaling·Gerd Schmitz, Margot Grandl
Mar 3, 2006·Surgical Infections·Patrick McHugh, Matthias Turina
Apr 6, 2004·Molecular Biology of the Cell·Xiaoxuan FanRobert A Schlegel
Jan 1, 2009·Molecular Biology of the Cell·Sean R StowellRichard D Cummings
Oct 27, 2011·Cardiovascular Research·Anna ZampetakiManuel Mayr
Jan 24, 2013·Cardiovascular Research·Hasan MahmudRudolf A de Boer
Apr 23, 2003·Current Opinion in Rheumatology·Anja BaierThomas Pap
Jun 27, 2002·Transplantation·Marc A R C DaemenWim A Buurman
Dec 19, 2006·Shock·Patrice PétillotRémi Neviere
Apr 14, 2010·Shock·Kevin R KastenCharles C Caldwell
Mar 6, 2003·Vox Sanguinis·Walter H DzikFrancesco Puppo
Feb 23, 2011·Development, Growth & Differentiation·Yoshinobu NakanishiAkiko Shiratsuchi
Jun 1, 2006·Acta Physiologica·Florian LangThomas Wieder
Jun 30, 2007·The Journal of Pharmacology and Experimental Therapeutics·Sandra ClaroRaouf Ali Khalil
Oct 20, 2007·Science·Bingsheng ChangRichard K Bruick
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Yoshiko TsuchihashiTsuyoshi Nagatake
Oct 24, 2007·Infection and Immunity·Deirdre M KellyJoseph Keane
Jan 24, 2003·Infection and Immunity·Christopher D HustonWilliam A Petri
Dec 23, 2003·Infection and Immunity·Whitney GreeneGuangming Zhong
Apr 10, 2009·Journal of Virology·Stéphane Pillet, Veronika von Messling
May 24, 2013·Journal of Virology·Sharof M TugizovJoel M Palefsky
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J E Vance, Dennis E Vance
Oct 20, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Claudio A HetzAndrew F G Quest
Dec 2, 2009·Annual Review of Immunology·Claudia KemperDennis E Hourcade
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Peter W Reddien, H R Horvitz
Feb 28, 2002·Annual Review of Immunology·Pierre GuermonprezS Amigorena
Mar 23, 2004·Annual Review of Immunology·Sergio A QuezadaRandolph J Noelle
Mar 18, 2005·Annual Review of Immunology·P R TaylorSiamon Gordon
Mar 23, 2006·Annual Review of Immunology·Ming O LiRichard A Flavell
Dec 10, 2002·Annual Review of Physiology·Krishnakumar Balasubramanian, Alan J Schroit
Apr 25, 2008·American Journal of Physiology. Renal Physiology·H Thomas LeeMihwa Kim
Dec 14, 2004·International Archives of Allergy and Immunology·Masahito MoriTetsuya Uchida
Jun 16, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Karl S LangFlorian Lang
Aug 18, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Philipp A LangThomas Wieder
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jan P NicolayFlorian Lang
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ekaterina ShumilinaFlorian Lang
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Peter J BentzenFlorian Lang
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jan P NicolayFlorian Lang
Jul 12, 2007·American Journal of Nephrology·H Thomas LeeCharles W Emala
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Philipp AttanasioFlorian Lang
Jan 23, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Michael FöllerStephan M Huber
Jan 23, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Olivier M NiemoellerFlorian Lang
Mar 6, 2008·Kidney & Blood Pressure Research·Michael FöllerFlorian Lang
Nov 11, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ravi S Kasinathan, Robert M Greenberg
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sergios GatidisFlorian Lang
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Christine ZelenakFlorian Lang
Jun 27, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Marleen StraatNicole P Juffermans
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Thomas L CroxtonJohn R Hoidal
Jul 26, 2005·American Journal of Respiratory and Critical Care Medicine·Mai-Lan N HuynhSally E Wenzel
Oct 7, 2003·American Journal of Respiratory Cell and Molecular Biology·B HuJ L Curtis
Nov 26, 2004·American Journal of Respiratory Cell and Molecular Biology·Jeffrey H JenningsJ L Curtis
Jun 23, 2000·The Journal of Clinical Investigation·J F Kearney
Jan 10, 2002·The Journal of Clinical Investigation·Mai-Lan N HuynhPeter M Henson
Mar 6, 2002·The Journal of Clinical Investigation·R William VandivierPeter M Henson
Oct 3, 2001·The Journal of Clinical Investigation·Valerie A FadokPeter M Henson
May 24, 2011·Malaria Journal·Adil BallalFlorian Lang
May 16, 2009·Malaria Journal·Diwakar BobbalaFlorian Lang
May 13, 2010·Malaria Journal·Ioana AlesutanFlorian Lang
Jul 15, 2003·Kinetoplastid Biology and Disease·M A BarcinskiAdriana C Bonomo
Nov 21, 2013·Acta Neuropathologica Communications·Jeroen F J BogieJerome J A Hendriks
Jul 1, 2004·Arthritis Research & Therapy·Marina Botto
May 19, 2005·Arthritis Research & Therapy·René J BerckmansPaul P Tak
May 25, 2012·Breast Cancer Research : BCR·Yi Fang LeeKartiki V Desai
Sep 30, 2004·Journal of Biology·Patrick L Williamson, Robert A Schlegel
Sep 10, 2003·Journal of Leukocyte Biology·Jacob D JohnsonJoan M Cook-Mills
Nov 26, 2010·Journal of Leukocyte Biology·Lee M OcuinRonald P DeMatteo
Mar 21, 2003·Pediatric Research·Boris W KramerMachiko Ikegami
May 26, 2006·Journal of Cell Science·David K MossJon D Lane
Jun 26, 2002·Biological & Pharmaceutical Bulletin·Masatoshi BeppuKiyomi Kikugawa
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Masaki OtsukaYukihiko Aramaki
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Akiko Yamaji-Hasegawa, Masafumi Tsujimoto
Mar 2, 2006·Biological & Pharmaceutical Bulletin·Masaki OtsukaYukihiko Aramaki
Nov 3, 2009·Biological & Pharmaceutical Bulletin·Masato HommaYukinao Kohda
Apr 2, 2009·Biological Chemistry·Andreas WeigertBernhard Brüne
Sep 1, 2005·Journal of Zhejiang University. Science. B·Wen-Jin Zhang, Shu-Sen Zheng
Oct 1, 2010·Molecular Medicine·Akihisa MatsudaPing Wang
Mar 26, 2002·American Journal of Veterinary Research·Kaat Van OostveldtChristian Burvenich
Mar 1, 2012·Journal of Pharmacology & Pharmacotherapeutics·Christo Paul PreethyMohammad Abdulkader Akbarsha
Jan 15, 2014·Advances in Therapy·Erdinc YenidoganHuseyin Ayhan Kayaoglu
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shulamit B Wallach-DayanRaphael Breuer
Jul 9, 2009·Bioscience, Biotechnology, and Biochemistry·Mat YamageMinoru Yamakawa
Mar 4, 2014·Reproductive Biomedicine Online·Xavier VendrellMiguel Ruiz-Jorro
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·B A CoccaMarko Radic
Apr 15, 2014·Nanoscale Research Letters·Andrei Maiseyeu, Vaishali Bagalkot
Dec 24, 2013·Antioxidants & Redox Signaling·Florian LangMichael Föller
Jan 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christina T MosesAlexander Khoruts
May 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·R S HotchkissI E Karl
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·B C UrbanD J Roberts
Aug 2, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Abby D Fuller, Linda J Van Eldik
Jan 12, 2011·Annual Review of Immunology·Roman BarbalatGregory M Barton
Dec 3, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Manuel BraunFlorian Lang
Feb 14, 2002·Seminars in Oncology·David G MaloneyAndrea Rose
Aug 28, 2010·Journal of Gastroenterology·Ana LleoM E Gershwin
Oct 14, 2010·Seminars in Immunopathology·Benjamin Frey, Udo S Gaipl
Feb 5, 2013·Cellular and Molecular Life Sciences : CMLS·Buvana Ravishankar, Tracy L McGaha
Mar 13, 2008·Médecine sciences : M/S·Arnaud A MailleuxJoan S Brugge
Oct 17, 2007·Médecine sciences : M/S·Omar BenzakourValérie Coronas
Mar 5, 2004·Médecine sciences : M/S·Maria Carmen MartínezJean-Marie Freyssinet
Feb 13, 2010·Journal of Liposome Research·Chantal J DicaireG Dennis Sprott
May 12, 2011·International Reviews of Immunology·Cheryl Lai-Lai ChiangGeorge Coukos
Oct 1, 2005·Journal of Liposome Research·Xuedong YanJan A A M Kamps
Jul 13, 2000·The Journal of Cell Biology·D R Green
Sep 8, 2015·Vaccines·Cheryl Lai-Lai ChiangLana E Kandalaft
Dec 1, 2008·Expert Review of Respiratory Medicine·Jeong H YunRubin M Tuder
Mar 14, 2002·Expert Opinion on Biological Therapy·Philippe SaasMarcelo de Carvalho Bittencourt
Jun 19, 2004·Journal of Drug Targeting·Lakshmi KrishnanInstitute for Biological Sciences, National Research Council of Canada
Nov 14, 2001·The Journal of Cell Biology·Selin Somersan, Nina Bhardwaj
Aug 29, 2003·Expert Opinion on Biological Therapy·Michael A ChattergoonDavid B Weiner
Sep 26, 2006·COPD·Peter J Barnes
Jan 2, 2010·FEBS Letters·F-Xabier ContrerasFélix M Goñi
Jul 7, 2007·Archives of Andrology·Melissa L VadnaisGary C Althouse
Jan 6, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D J NaisbittB K Park
Dec 18, 2015·Biomolecular Concepts·Philipp RohneClaudia Koch-Brandt
Mar 5, 2014·Hematology/oncology Clinics of North America·F A Kuypers
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Longxing CaoYongning He
Oct 9, 2012·Blood Cells, Molecules & Diseases·Marie-Catherine GiarratanaLuc Douay
Feb 20, 2009·Journal of Neuropathology and Experimental Neurology·Mark R GriffithsJames W Neal
Oct 29, 2005·Journal of Neuropathology and Experimental Neurology·Shumin DongDavid N Louis
Apr 4, 2012·Burns : Journal of the International Society for Burn Injuries·Cemal FiratYusuf Kenan Coban
Sep 3, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·L LeveelahtiM Nikinmaa
Mar 17, 2011·Biochemical and Biophysical Research Communications·Weiyan Peng, Lanping Amy Sung
Jul 29, 2005·The American Journal of Pathology·Diana M FriesHarry Ischiropoulos
Nov 26, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Puneet GaitondeSathy V Balu-Iyer
Nov 8, 2015·Pharmacology & Therapeutics·Maryam DarabiAnatol Kontush
Jun 26, 2010·Biochimica Et Biophysica Acta·Kaustav Dutta ChowdhuryTuli Biswas
Apr 2, 2010·Seminars in Immunology·Cheryl Lai-Lai ChiangGeorge Coukos
Mar 27, 2010·Nutrition·Hasan MahmudFlorian Lang
Mar 5, 2016·Molecular Cell·Patrick D Bhola, Anthony Letai
Sep 22, 2009·European Journal of Pharmacology·Syed M QadriFlorian Lang
Apr 11, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Syed M QadriFlorian Lang
May 5, 2009·Life Sciences·Syed M QadriFlorian Lang
Feb 28, 2009·European Journal of Radiology·Robbert MeerwaldtClark J Zeebregts
Nov 13, 2008·The Journal of Allergy and Clinical Immunology·Andrew H Liu
Sep 16, 2008·Cellular Signalling·Vassilis J Marmaras, Maria Lampropoulou
Aug 30, 2008·Cancer Treatment Reviews·Elza C de Bruin, Jan Paul Medema
Aug 12, 2008·Molecular Immunology·Claudia Kemper, Dennis E Hourcade
Jun 3, 2008·Journal of Autoimmunity·Ana LleoM E Gershwin
May 24, 2008·Toxicology·Hasan MahmudFlorian Lang
May 10, 2008·Biochimie·Jean-Luc Jestin
Jan 1, 2007·Drug Discovery Today. Disease Mechanisms·Mario PerlAlfred Ayala
Feb 19, 2008·Trends in Cell Biology·Michael R Elliott, K S Ravichandran
Apr 24, 2007·La Presse médicale·Patrick BlancoJean-François Viallard
Jan 22, 2008·Toxicology·Mentor SopjaniFlorian Lang
Jan 22, 2008·European Journal of Pharmacology·Michael FöllerFlorian Lang
Dec 4, 2015·Macromolecular Bioscience·Raquel Palao-SuayJulio San Román
Aug 8, 2007·Medical Hypotheses·E Sun
Apr 21, 2007·Biochemical and Biophysical Research Communications·Saisudha KokaFlorian Lang
Feb 6, 2007·Current Opinion in Biotechnology·Maarten F CorstenLeonard Hofstra
Feb 24, 2007·Archives of Biochemistry and Biophysics·Florian LangE Gulbins
Aug 2, 2006·Clinics in Chest Medicine·Casey W Melton, Johnson Haynes
Mar 28, 2007·Heart Failure Clinics·Luanda P Grazette, Anthony Rosenzweig
Dec 2, 2006·Experimental Cell Research·Takayuki KuraishiYoshinobu Nakanishi
Oct 7, 2015·Trends in Cell Biology·Katsumori Segawa, Shigekazu Nagata
Nov 7, 2003·Developmental Cell·Cory J EvansUtpal Banerjee
Aug 18, 2004·Immunology·Christopher D Gregory, Andrew Devitt
Mar 26, 2005·Immunological Reviews·Ian R RifkinAnn Marshak-Rothstein
Jul 23, 2004·Aging Cell·Khurram Ayub, Maurice B Hallett
Mar 26, 2005·Molecular Reproduction and Development·Akihisa NakagawaYoshinobu Nakanishi
Mar 12, 2005·Cellular Microbiology·Gordon D Brown, Siamon Gordon
May 5, 2005·Journal of Thrombosis and Haemostasis : JTH·Y S Ahn
Dec 18, 2003·Immunology·Khurram Ayub, Maurice B Hallett
Mar 27, 2009·Journal of Cellular and Molecular Medicine·Michael FöllerFlorian Lang
Apr 29, 2009·European Journal of Clinical Investigation·Michael FöllerFlorian Lang
Jun 25, 2009·British Journal of Haematology·Latorya A BarberRobert S Franco
May 16, 2009·Journal of Applied Toxicology : JAT·Mentor SopjaniFlorian Lang
Mar 11, 2004·Cellular Microbiology·Philipp A LangStephan M Huber
Jan 24, 2004·Clinical and Experimental Immunology·S P HartI Dransfield
May 20, 2006·Journal of Peptide Science : an Official Publication of the European Peptide Society·Shinichi KuriyamaTakuro Niidome
May 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takashi TakeuchiShunzo Kondo
Aug 23, 2008·IUBMB Life·Michael FöllerFlorian Lang
May 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Gordana KocicSvetlana Stojanovic
Feb 15, 2007·Journal of Cellular Physiology·Liudmila ZakharovaAlla F Fomina
Apr 29, 2006·British Journal of Haematology·Kitty de Jong, F A Kuypers
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·Valery LeytinJohn Freedman
Dec 29, 2007·The Journal of Pathology·E ManiatiB J Morley
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adrian E Morelli
Mar 17, 2010·Biotechnology and Bioengineering·Julianne F AudiffredW Todd Monroe
May 11, 2011·The Plant Journal : for Cell and Molecular Biology·Yasuyo YamaokaIkuo Nishida
Apr 27, 2011·Journal of Cellular Physiology·Wei Li
Aug 5, 2010·International Journal of Laboratory Hematology·D SaganOrathai Tangvarasittichai
Jul 26, 2011·Journal of Cellular and Molecular Medicine·Syed M QadriFlorian Lang
Mar 14, 2013·Clinical and Experimental Immunology·G-H RongM E Gershwin
May 6, 2011·American Journal of Hematology·Erfan NurCURAMA Study Group
Oct 21, 2010·Annals of the New York Academy of Sciences·D MevorachInna Verbovetski-Reiner
Apr 7, 2011·European Journal of Immunology·Chikako Matsuzaki-MoriyaHajime Hisaeda
Jan 6, 2007·Biochemical and Biophysical Research Communications·Yoichiro HaradaKen Kitajima
Mar 3, 2010·Immunological Reviews·Yan ShiGilbert Ng
Apr 27, 2005·Brain Research. Brain Research Reviews·Luisa MinghettiRoberta De Simone
Feb 22, 2005·Current Opinion in Neurobiology·Michel MallatCyril Chéret
Apr 15, 2005·Molecular Immunology·YuFeng PengKeith B Elkon
Apr 30, 2005·Immunology Letters·Mari GotohIsamu Matsumoto
Aug 16, 2005·Prostaglandins & Other Lipid Mediators·Daniele Piomelli
Feb 8, 2005·Medical Hypotheses·Lgnacio Eduardo BlancoJuan Carlos Torre
Jun 1, 2010·Acta Tropica·Diwakar BobbalaFlorian Lang
Oct 27, 2004·Biochemical and Biophysical Research Communications·Masaki OtsukaYukihiko Aramaki
Sep 30, 2004·International Immunopharmacology·P K Raveendran NairCheppail Ramachandran
Oct 12, 2004·Biochemical and Biophysical Research Communications·Sergio H SeabraRenato A Damatta
Oct 28, 2004·Thrombosis Research·Matthew C Cook
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Amy M Cline, Marko Radic
Sep 25, 2007·Biochemical and Biophysical Research Communications·Saisudha KokaFlorian Lang
Jun 1, 2005·The American Journal of Cardiology·Anthony E Bolton
Nov 25, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Murray S WebbM B Bally
Oct 24, 2006·The Journal of Surgical Research·Hongchi JiangXueying Sun
Oct 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Irene C B ViorrittoRichard M Siegel
Oct 24, 2006·Toxicology and Applied Pharmacology·Olivier M NiemoellerFlorian Lang
Sep 12, 2006·Biochimica Et Biophysica Acta·Jesús BalsindeMaría A Balboa
Aug 15, 2006·The Science of the Total Environment·Iván N Pérez-MaldonadoFernando Díaz-Barriga
Feb 14, 2006·European Journal of Pharmacology·Ahmad AkelFlorian Lang
Dec 28, 2005·Immunology Letters·Gyöngyike MájaiLászló Fésüs
Dec 29, 2005·Experimental Cell Research·Heidi KenisChris P M Reutelingsperger
Oct 26, 2005·Journal of Autoimmunity·Amy N SanfordKathleen E Sullivan
Aug 13, 2005·Experimental Cell Research·Constance DelabyFrançois Canonne-Hergaux
Jan 15, 2002·Cardiology Clinics·X RoucouJ C Martinou
Jun 28, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Paola Maderna, Catherine Godson
Jun 14, 2005·Experimental Cell Research·Olivier Gasser, Jürg A Schifferli
Apr 6, 2004·Rheumatic Diseases Clinics of North America·Jeannine S NavratilJoseph M Ahearn
Jul 21, 2004·Rheumatic Diseases Clinics of North America·Philip L Cohen, R Caricchio
Jul 21, 2004·Rheumatic Diseases Clinics of North America·A SheriffMartin Herrmann
Jul 21, 2004·Rheumatic Diseases Clinics of North America·Robert M Clancy, Jill P Buyon
Sep 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei DongBaosheng Li
Apr 6, 2012·Biochemical and Biophysical Research Communications·Yoko NishimuraNaohide Hirashima
Sep 24, 2015·BMC Pharmacology & Toxicology·Paulo Cm UrbanoValderilio F Azevedo
Nov 23, 2011·Cellular & Molecular Biology Letters·Mehrdad GhashghaeiniaThomas Wieder
Mar 5, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Andrea GramaticaSalvatore Chiantia
Dec 17, 2014·Acta histochemica·María Clara CarouDaniel Marcelo Lombardo
May 23, 2015·The Biochemical Journal·Angelika BöttgerAlexander Wolf
Jul 16, 2011·International Journal of Alzheimer's Disease·Olga Simakova, Nelson J Arispe
Nov 16, 2001·Seminars in Immunology·Valerie A Fadok, Giovanna Chimini
Nov 16, 2001·Seminars in Immunology·C Watts, S Amigorena
Oct 3, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Serafina PerroneGiuseppe Buonocore
May 10, 2005·Bioorganic & Medicinal Chemistry·Kristy M DiVittorioBradley D Smith
Sep 16, 2008·Biochemical and Biophysical Research Communications·Diwakar BobbalaFlorian Lang
Aug 30, 2000·Lancet·H W StraussF G Blankenberg
Oct 11, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Patrick KeeDelia Danila
Aug 8, 2002·Neuron·Tony Wyss-Coray, Lennart Mucke
Mar 10, 2009·Biochimica Et Biophysica Acta·Caroline LonezJean-Marie Ruysschaert
Dec 1, 2001·Current Biology : CB·J M de Freitas BalancoM A Barcinski
Sep 23, 2003·Immunity·Gordon D Brown, Siamon Gordon
Oct 10, 2001·Current Biology : CB·Peter M HensonValerie A Fadok
Dec 21, 2007·Immunity·John Savill, Chris Gregory
Aug 27, 2013·Immunity·Yuting MaGuido Kroemer
Mar 13, 2014·Methods : a Companion to Methods in Enzymology·Cory J EvansUtpal Banerjee
Jan 9, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M G van der VaartC J Zeebregts
Mar 17, 2010·Current Biology : CB·Tsung-Yuan Hsu, Yi-Chun Wu
Jan 24, 2008·Current Biology : CB·Donna L Bratton, Peter M Henson
Feb 1, 2015·Seminars in Cell & Developmental Biology·Elisabeth Lang, Florian Lang
Apr 12, 2003·Developmental Cell·Swathi ArurDavid K Han
May 6, 2004·Molecular Cell·Kirsten LauberSebastian Wesselborg
Dec 12, 2003·Cancer Cell·Jason A HoffmanErkki Ruoslahti
Nov 26, 2003·Biochimica Et Biophysica Acta·Paola Maderna, Catherine Godson
Mar 10, 2010·Cell·Shigekazu NagataKohki Kawane
Feb 1, 2015·Apoptosis : an International Journal on Programmed Cell Death·Elisabeth LangFlorian Lang
Mar 27, 2012·Toxicon : Official Journal of the International Society on Toxinology·Erika S NunesMaria T S Correia
Jan 28, 2004·Cell·Nika N Danial, Stanley J Korsmeyer
Jun 19, 2007·Cell·Wei Li, Nicholas E Baker
Feb 19, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ana Lleo, Pietro Invernizzi
Aug 6, 2010·Journal of Molecular Biology·Monica MantriChristopher J Schofield
Feb 2, 2011·Biophysical Journal·Wayland W L ChengColin G Nichols
Jan 6, 2009·Biochemical and Biophysical Research Communications·Kavita BishtWoo S Koh
Nov 16, 2010·Biochimica Et Biophysica Acta·Igor Vorobyov, Toby W Allen
Dec 4, 2002·Nature Reviews. Immunology·John SavillChris Haslett
Mar 31, 2015·BioMed Research International·Elisabeth Lang, Florian Lang
Apr 9, 2001·Seminars in Cell & Developmental Biology·T PomorskiG van Meer
Nov 27, 2014·Frontiers in Immunology·Stanley Gititu KimaniRaymond B Birge
Jun 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Claudia KemperDennis E Hourcade
Sep 15, 2004·FEMS Immunology and Medical Microbiology·Thaís Helena GasparotoIonice Felipe
Apr 28, 2016·Seminars in Immunopathology·C T RobbA G Rossi
Nov 22, 2015·Journal of Cellular Biochemistry·K SanjanaSudip K Ghosh
Jun 6, 2016·Biochimica Et Biophysica Acta·Rajeshwari Taruvai Kalyana KumarShalini Prasad
Feb 13, 2016·Cell Death and Differentiation·F Martín-SánchezP Pelegrín
Nov 30, 2005·The American Journal of Pathology·Ikuo TsunodaRobert S Fujinami
Sep 21, 2016·Trends in Cell Biology·Georgia K Atkin-Smith, Ivan K H Poon
Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Longxing CaoYongning He
Dec 29, 2016·Nature Reviews. Immunology·Lorenzo GalluzziGuido Kroemer
Mar 18, 2006·The Journal of Chemical Physics·M Hase, K Yoshikawa
Feb 7, 2017·Expert Review of Clinical Immunology·Ludger KlimekMatthew D Heath
Mar 2, 2017·International Journal of Molecular Sciences·Revathy Guruswamy, Ayman ElAli
Jan 23, 2017·Ageing Research Reviews·Gennadii Petrovich GusevNatalia Ivanovna Agalakova
Dec 21, 2016·Journal of Biomedical Materials Research. Part a·Hongxuan QuanHyeong-Cheol Yang
Mar 30, 2004·Anais Da Academia Brasileira De Ciências·M E C Moreira, M A Barcinski
Jun 4, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J L M WanderleyM A Barcinski
Sep 21, 2006·Nature Reviews. Genetics·Robert J KloseYi Zhang
Oct 9, 2013·Journal of Lipid Research·Mijin Son, Erwin London
Apr 7, 2009·Journal of Psychopharmacology·Jan P NicolayU E Lang
Sep 10, 2003·International Reviews of Immunology·A Hajime KoyamaHiroshi Irie
Sep 10, 2003·International Reviews of Immunology·Martine Aubert, Keith R Jerome
Jan 1, 2011·Cancers·Kenneth J O'ByrneSteven G Gray
Dec 1, 2001·Nature Medicine·T LawrenceD A Willoughby
Apr 12, 2001·The Journal of Biological Chemistry·A C Tosello-TrampontK S Ravichandran
Feb 6, 2018·Annual Review of Immunology·Shigekazu Nagata
May 2, 2007·The Journal of Biological Chemistry·Krishnakumar BalasubramanianAlan J Schroit
Jan 30, 2008·Current Protocols in Cell Biology·Boris Zhivotovsky, Sten Orrenius