A Recipient Risk Prediction Tool for Short-term Mortality After Pediatric Heart Transplantation

Transplantation
Swati ChoudhryWilliam J Dreyer

Abstract

The first year after heart transplantation (HT) has the highest risk of mortality. We aim to derive and validate a recipient risk prediction tool for early mortality after pediatric HT. The International Society for Heart and Lung Transplantation (ISHLT) registry was used to identify patients (≤18 y) who underwent primary HT during January 2000-December 2014. Independent predictors of 1-year mortality were identified based on recipient characteristics at HT. Risk scores were assigned based on the magnitude of relative odds of 1-year mortality. The predictive capability of the ISHLT registry derived recipient risk score was externally validated using the Scientific Registry of Transplant Recipients registry data from 2015 to 2017 to ensure a cohort of patients completely exclusive from the derivation cohort. A total of 5045 eligible patients were included in the analysis. The 20-point risk scoring system incorporated 8 recipient variables, including age at HT, diagnosis, pre-HT ventilator use, extracorporeal membrane oxygenation, inhaled nitric oxide use, infection, estimated glomerular filtration rate, and serum bilirubin. Compared with low-risk score group, high-risk group had 7-fold increased risk of 1-year mortality (hazard ...Continue Reading

References

Mar 14, 2007·Transplantation·Richard Borrows, Paul Cockwell
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Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkMarshall I Hertz
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Oct 19, 2011·Pediatric Transplantation·Brian FeingoldUNKNOWN Pediatric Heart Transplant Study Investigators
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C S AlmondT P Singh
Apr 9, 2013·Journal of the American College of Cardiology·Margaret S KimP Christian Schulze
Sep 24, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Anne I DipchandUNKNOWN International Society for Heart and Lung Transplantation
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Nov 4, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Salil V DeoSoon J Park
Mar 22, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Conall T MorganAnne I Dipchand
Oct 23, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Swati ChoudhryCharles E Canter

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Citations

May 4, 2021·Current Opinion in Organ Transplantation·John D Cleveland, S Ram Kumar
May 20, 2021·Current Opinion in Organ Transplantation·John D Cleveland, S Ram Kumar
Jun 14, 2021·Pediatric Transplantation·Swati ChoudhrySusan W Denfield
Dec 10, 2021·Pediatric Transplantation·Alia DaniFarhan Zafar

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