A reciprocal inhibition model of alternations between under-/overemotional modulatory states in patients with PTSD.

Molecular Psychiatry
T. ChibaAi Koizumi

Abstract

Patients with posttraumatic stress disorder (PTSD) appear to manifest two opposing tendencies in their attentional biases and symptoms. However, whether common neural mechanisms account for their opposing attentional biases and symptoms remains unknown. We here propose a model in which reciprocal inhibition between the amygdala and ventromedial prefrontal cortex (vmPFC) predicts synchronized alternations between emotional under- and overmodulatory states at the neural, behavioral, and symptom levels within the same patients. This reciprocal inhibition model predicts that when the amygdala is dominant, patients enter an emotional undermodulatory state where they show attentional bias toward threat and manifest re-experiencing symptoms. In contrast, when the vmPFC is dominant, patients are predicted to enter an emotional overmodulatory state where they show attentional bias away from threat and avoidance symptoms. To test the model, we performed a behavioral meta-analysis (total N = 491), analyses of own behavioral study (N = 20), and a neuroimaging meta-analysis (total N = 316). Supporting the model, we found the distributions of behavioral attentional measurements to be bimodal, suggesting alternations between the states within...Continue Reading

References

Dec 16, 1977·Biological cybernetics·W O Friesen, G S Stent
Dec 1, 2001·Current Biology : CB·E Marder, D Bucher
Jul 12, 2002·European Archives of Psychiatry and Clinical Neuroscience·Anna PissiotaMats Fredrikson
Nov 8, 2002·Nature·Mohammed R Milad, Gregory J Quirk
Dec 10, 2003·Neuroreport·Hackjin KimPaul J Whalen
Sep 8, 2004·Behaviour Research and Therapy·Ernst H W KosterJan De Houwer
Jul 5, 2005·Nature Neuroscience·Naotsugu Tsuchiya, Christof Koch
Aug 8, 2006·Annals of the New York Academy of Sciences·Paul A Frewen, Ruth A Lanius
Jan 5, 2007·Psychological Bulletin·Yair Bar-HaimMarinus H van IJzendoorn
May 30, 2007·American Journal of Ophthalmology·Olga SeijasEster Diaz
Jul 11, 2008·Nature·Cyril HerryAndreas Lüthi
Dec 27, 2008·NeuroImage·Amy Krain RoyMichael P Milham
Feb 17, 2009·Neuroreport·Frida E PolliDara S Manoach
Sep 15, 2009·Biological Psychiatry·Mohammed R MiladScott L Rauch
Mar 9, 2010·Nature Neuroscience·Taiju AmanoDenis Paré
Apr 3, 2010·The American Journal of Psychiatry·Ruth A LaniusDavid Spiegel
Oct 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Demetrio Sierra-MercadoGregory J Quirk
Nov 12, 2010·Nature·Stephane CiocchiAndreas Lüthi
Mar 29, 2011·Neuropsychologia·Myriam El Khoury-MalhameStephanie Khalfa
Feb 9, 2012·Journal of Psychiatry & Neuroscience : JPN·Rebecca K SripadaIsrael Liberzon
Mar 15, 2012·Biological Psychology·Negar FaniKerry J Ressler
Jun 29, 2012·Biology of Mood & Anxiety Disorders·Jasmeet P HayesAmanda M Mikedis
Oct 13, 2012·Biological Psychiatry·Dan J SteinRonald C Kessler
Nov 28, 2012·Neuron·Francisco Sotres-BayonGregory J Quirk
Mar 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dylan G GeeNim Tottenham
Jul 6, 2013·Journal of Psychiatric Research·Jennifer S StevensKerry J Ressler
Aug 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa M BrownRajendra A Morey
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jennifer Strafford StevensKerry J Ressler
Mar 8, 2014·Journal of Traumatic Stress·Brian M IacovielloDennis S Charney
Oct 7, 2014·Emotion·Liliana P CapitãoSusannah E Murphy
Feb 27, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabricio H Do-MonteGregory J Quirk
Mar 20, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew A NicholsonRuth A Lanius
Jul 15, 2015·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Hwallip BaeYong Chon Park
Jul 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard C Wolf, Ryan J Herringa
Jul 25, 2015·The American Journal of Psychiatry·Reut NaimYair Bar-Haim

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