PMID: 18196971Jan 17, 2008Paper

A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer

Cell Cycle
Richard K Assoian, Yuval Yung

Abstract

The identification of Skp2 as a direct E2F target has allowed us to document the existence of a positive feedback loop comprised of Rb-E2F, Skp2, p27 and cyclin E-cdk2. We have termed this set of regulatory molecules the Skp2 autoinduction loop. Interference with this loop selectively regulates cell cycle progression through the restriction point. We describe here how the Skp2 autoinduction loop may interact with other regulatory controls on the restriction point, and how the reciprocal relationship between Rb and Skp2 may affect signal transduction to the cell cycle and thinking about the role of Skp2 overexpression in cancers.

Citations

Sep 9, 2008·Apoptosis : an International Journal on Programmed Cell Death·Richard A Lockshin
Oct 22, 2010·Molecular Biology of the Cell·Chiao Yun LinBenjamin Yat-Ming Yung
Dec 10, 2009·Pigment Cell & Melanoma Research·Yann CheliCorine Bertolotto
Feb 9, 2012·Cancer Research·Hana Totary-JainAndrew R Marks
Apr 21, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Eun ShinKyungbun Lee
Jun 22, 2010·Journal of Cellular Biochemistry·Monika KüppersCornelia Dietrich
Sep 1, 2015·Biochimica Et Biophysica Acta·Satyaki Sengupta, R William Henry
Aug 6, 2017·Cell and Tissue Research·Marcela S ProcópioLuiz R de França
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Oluf Dimitri Røe, Giulia Maria Stella
Dec 29, 2011·The Journal of Biological Chemistry·Dianhua QiaoAndreas Friedl
Aug 14, 2020·Journal of Clinical Medicine·Zihao Chen, Chunhe Li
Jun 11, 2021·Frontiers in Cell and Developmental Biology·Tatyana BodrugNicholas G Brown

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