A recombinant anti-ICAM-1 Fab fragment is as effective as the complete IgG antibody in treatment of burns in rabbits

Burns : Journal of the International Society for Burn Injuries
P Ch FuchsN Pallua

Abstract

The purpose of this study was to examine the efficiency of an Anti-ICAM-1-Fab fragment in the treatment of burns. Blocking ICAM-1 using murine IgG with the purpose to prevent further damage to the zone of stasis has proven its effectiveness in animal models as well as in humans. The use of murine Antibodies has some disadvantages including allergic reactions and complement activation. For the first time we examined an industry produced Fab-fragment blocking ICAM-1 and compared it to the corresponding IgG antibody. We showed in a standardised rabbit burn model that an Fab-fragment is capable of blocking ICAM-1 and therefore improving the reaction of the skin to trauma in the zone of stasis.

References

May 1, 1992·The Journal of Trauma·F C Regas, H P Ehrlich
May 1, 1985·Prostaglandins·M BraquetP Braquet
Dec 1, 1987·Genitourinary Medicine·A C McCartneyI B Tait
Jun 1, 1985·Burns, Including Thermal Injury·G Arturson
Jan 1, 1973·Experientia·A A Hakim
Oct 1, 1983·The Journal of Trauma·J R SarantoB E Zawacki
Aug 1, 1995·The Journal of Trauma·F E NwariakuP E Lipsky
Nov 1, 1993·The Journal of Burn Care & Rehabilitation·W MileskiC Baxter
Aug 1, 1994·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·W J MileskiP Lipsky
Mar 1, 1994·Journal of Critical Care·R J KorthuisD N Granger
Jun 18, 1999·The Journal of Trauma·M R JerathN S Nishioka
Jan 12, 2000·Burns : Journal of the International Society for Burn Injuries·J S KnablM Frey
May 5, 2000·Biomolecular Engineering·A Skerra, T G Schmidt
Aug 18, 2000·The Journal of Surgical Research·H BaskaranF Berthiaume
May 12, 2001·Burns : Journal of the International Society for Burn Injuries·J M StillJ Z Holtz
Jan 27, 2004·The Journal of Pathology·Madhav Bhatia, Shabbir Moochhala
Jul 5, 2005·Burns : Journal of the International Society for Burn Injuries·Qiren HuangYucheng Dai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.