A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea

The Journal of Infectious Diseases
Blaise GentonMichael P Alpers

Abstract

The malaria vaccine Combination B comprises recombinant Plasmodium falciparum ring-infected erythrocyte surface antigen and 2 merozoite surface proteins (MSP1 and MSP2) formulated in oil-based adjuvant. A phase 1-2b double-blind, randomized, placebo-controlled trial in 120 children (5-9 years old) in Papua New Guinea demonstrated a 62% (95% confidence limits: 13%, 84%) reduction in parasite density in children not pretreated with sulfadoxine-pyrimethamine. Vaccinees had a lower prevalence of parasites carrying the MSP2-3D7 allelic form (corresponding to that in the vaccine) and a higher incidence of morbid episodes associated with FC27-type parasites. These results demonstrate functional activity of Combination B against P. falciparum in individuals with previous malaria exposure. The specific effects on parasites with particular msp2 genotypes suggest that the MSP2 component, at least in part, accounted for the activity. The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types.

Citations

Jun 14, 2005·Current Opinion in Immunology·Christian R Engwerda, Michael F Good
May 6, 2006·Trends in Parasitology·Spencer D PolleyColin J Sutherland
Nov 2, 2013·Trends in Parasitology·Danielle I StanisicMichael F Good
Oct 16, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·L HenningI Felger
Mar 23, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R RanjitG P Chhotray
Nov 19, 2002·International Journal for Parasitology·Sócrates HerreraMyriam Arévalo-Herrera
Feb 15, 2003·Trends in Parasitology·Ingrid FelgerHans Peter Beck
Jun 12, 2003·Trends in Parasitology·John C Reeder
Jun 12, 2003·Trends in Parasitology·Alfred CortésHans-Peter Beck
Jun 12, 2003·Trends in Parasitology·Blaise GentonJohn C Reeder
Sep 11, 2002·The Lancet Infectious Diseases·Philippe J GuerinNicholas J White
May 7, 2009·Immunology and Cell Biology·Jack S Richards, James G Beeson
Feb 8, 2013·Nature Medicine·Eleanor M Riley, V Ann Stewart
Sep 16, 2011·The New England Journal of Medicine·Mahamadou A TheraChristopher V Plowe
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter D CromptonSusan K Pierce
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ivo MuellerIngrid Felger
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret J Mackinnon, Andrew F Read
Sep 7, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adrian V S Hill
Jan 16, 2007·Clinical Microbiology Reviews·David J Conway
May 20, 2009·Infection and Immunity·Vanessa SardáKim C Williamson
Jan 5, 2008·Infection and Immunity·Lisa A PurcellAna Rodriguez
Jun 23, 2006·Infection and Immunity·Thomas M KariukiPatricia S Coulson
Oct 27, 2004·Infection and Immunity·Christian FlückIngrid Felger
Mar 25, 2004·Infection and Immunity·J Andrew PearceRobin F Anders
Aug 7, 2002·The Journal of Clinical Investigation·Magdalena PlebanskiGraham Flannery

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