PMID: 15331566Aug 28, 2004Paper

A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis

Diabetes
Laurie L BaggioDaniel J Drucker

Abstract

Peptide hormones exert unique actions via specific G protein-coupled receptors; however, the therapeutic potential of regulatory peptides is frequently compromised by rapid enzymatic inactivation and clearance from the circulation. In contrast, recombinant or covalent coupling of smaller peptides to serum albumin represents an emerging strategy for extending the circulating t(1/2) of the target peptide. However, whether larger peptide-albumin derivatives will exhibit the full spectrum of biological activities encompassed by the native peptide remains to be demonstrated. We report that Albugon, a human glucagon-like peptide (GLP)-1-albumin recombinant protein, activates GLP-1 receptor (GLP-1R)-dependent cAMP formation in BHK-GLP-1R cells, albeit with a reduced half-maximal concentration (EC(50)) (0.2 vs. 20 nmol/l) relative to the GLP-1R agonist exendin-4. Albugon decreased glycemic excursion and stimulated insulin secretion in wild-type but not GLP-1R(-/-) mice and reduced food intake after both intracerebroventricular and intraperitoneal administration. Moreover, intraperitoneal injection of Albugon inhibited gastric emptying and activated c-FOS expression in the area postrema, the nucleus of the solitary tract, the central nu...Continue Reading

References

Apr 1, 1993·Digestive Diseases and Sciences·A WettergrenJ J Holst
Mar 21, 1998·The Journal of Clinical Investigation·A FlintJ J Holst
Mar 22, 2001·Advanced Drug Delivery Reviews·U BickelW M Pardridge
Apr 5, 2002·Journal of Molecular Neuroscience : MN·Abba J KastinWeihong Pan
May 15, 2002·European Journal of Pharmacology·Juris J MeierMichael A Nauck
Jun 19, 2002·Pharmaceutical Research·Victor Tuan Giam ChuangMasaki Otagiri
Jul 18, 2002·The Journal of Biological Chemistry·Mark S DennisLisa A Damico
Sep 25, 2002·Bioorganic & Medicinal Chemistry Letters·Michael F T KoehlerRobert A Lazarus
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Blaire L OsbornCynthia Sung
Nov 1, 2002·The Journal of Biological Chemistry·Yazhou LiDaniel J Drucker
Nov 5, 2002·Brain Research·Jiapei DaiReinier O Schlingemann
Mar 12, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A J Kastin, V Akerstrom
Apr 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niels VrangHans-Rudolf Berthoud
May 15, 2003·Endocrinology·Robert GrosMansoor Husain
Sep 30, 2003·Diabetes Care·Daniel J Drucker

❮ Previous
Next ❯

Citations

Jan 10, 2013·Current Atherosclerosis Reports·Linde M MorsinkMichaela Diamant
Apr 29, 2010·Current Diabetes Reports·Mikkel Christensen, Filip K Knop
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Chrysi Koliaki, John Doupis
Nov 17, 2009·Nature Biotechnology·Volker SchellenbergerWillem P C Stemmer
Dec 11, 2007·Nature Biotechnology·G Mani SubramanianJohn G McHutchison
Aug 25, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Daniel J Drucker
Mar 13, 2013·Nature Reviews. Endocrinology·Sharon A Sadry, Daniel J Drucker
Jan 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Miriam AmiramAshutosh Chilkoti
Apr 26, 2008·Diabetes, Obesity & Metabolism·Kasper AaboeJens Juul Holst
Aug 7, 2012·Diabetes, Obesity & Metabolism·T A Lutz
May 26, 2010·The Journal of Pharmacology and Experimental Therapeutics·Byung-Joon KimJosephine M Egan
Dec 17, 2008·Pharmacological Reviews·Wook Kim, Josephine M Egan
Jul 13, 2011·Experimental Diabetes Research·Chinmay S MaratheMichael Horowitz
Dec 21, 2011·The Journal of Clinical Investigation·Benjamin J LamontDaniel J Drucker
Dec 15, 2010·BMC Endocrine Disorders·Deepson S ShyangdanNorman R Waugh
Dec 17, 2008·Endocrinology·Diana L WilliamsMichael W Schwartz
Apr 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Rania Abu-HamdahDariush Elahi
Nov 5, 2010·Biological & Pharmaceutical Bulletin·Tomokazu Tsurugizawa, Kunio Torii
Sep 22, 2010·PloS One·Qinghua WangGerald J Prud'homme
May 12, 2007·The Review of Diabetic Studies : RDS·Baptist Gallwitz
Sep 17, 2008·The Review of Diabetic Studies : RDS·Richard E Pratley, Matthew Gilbert
Dec 2, 2005·Treatments in Endocrinology·Baptist Gallwitz
Dec 11, 2013·The Journal of Endocrinology·L van BloemendaalM Diamant
May 28, 2014·Drugs·Raewyn M Poole, Mary L Nowlan
Feb 11, 2014·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Borje DarpoRickey R Reinhardt
Oct 27, 2012·Advanced Drug Delivery Reviews·Kwang-Chul KwonHenry Daniell
Jun 22, 2014·Acta Biochimica Et Biophysica Sinica·Rui LiuQinghua Wang
Sep 10, 2014·The Journal of Clinical Investigation·Anna SecherLotte Bjerre Knudsen
Nov 12, 2014·Postgraduate Medicine·Malcolm A YoungRickey R Reinhardt
Nov 18, 2015·Expert Review of Clinical Pharmacology·L ØstergaardS Madsbad
Jul 12, 2005·Expert Opinion on Investigational Drugs·Octaviano A RogesAthena Philis-Tsimikas
Oct 13, 2007·Expert Opinion on Pharmacotherapy·A Barnett
Apr 7, 2010·Expert Opinion on Biological Therapy·Erin L St Onge, Shannon A Miller
Mar 21, 2012·Expert Opinion on Drug Metabolism & Toxicology·Xiaoying ChenWei-Chiang Shen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.