A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland.

British Journal of Cancer
S A McDonaldD Goldberg

Abstract

We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record-linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first-time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 (average annual change of 6.1, 95% confidence interval (CI): 0.9-11.6%, P=0.021). The adjusted relative risk of HCC was greater for males (hazard ratio=2.7, 95% CI: 1.7-4.2), for those aged 60 years or older (hazard ratio=2.7, 95% CI: 1.9-4.1) compared with 50-59 years, and for those with a previous alcohol-related hospital admission (hazard ratio=2.5, 95% CI: 1.7-3.7). The risk of individuals diagnosed with HCV developing HCC was greatly increased compared with the general Scottish population (standardised incidence ratio=127, 95% CI: 102-156). Owing to the advancing age of the Scottish HCV-diagnosed population, the annual number of HCC cases is projected to i...Continue Reading

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Citations

Dec 17, 2009·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Kyoung-Mu LeeDaehee Kang
Sep 22, 2012·Current Neurology and Neuroscience Reports·Yohannes Woubishet Woldeamanuel
Sep 19, 2012·Journal of Clinical Nursing·Michael FlemingKay I Penny

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