A reduction in DNA damage in neural tissue and peripheral blood of old mice treated with caffeine

Journal of Toxicology and Environmental Health. Part a
Adriani Paganini DamianiVanessa Moraes de Andrade

Abstract

Studies on caffeine consumption have shown a negative correlation with development of some diseases with subsequent beneficial manifestations. Our aim was to assess the effects of caffeine on peripheral blood and neural tissue DNA in young adult and aged mice. Male Swiss mice (age 2-3 or 16-18 months, respectively) were treated with a caffeine solution (0.3 g/l) for 4 weeks, while controls received water. After the treatments, blood and hippocampal cells (for a comet assay) and femurs (for a micronucleus [MN] test) were collected. The comet assay of peripheral blood and hippocampal cells demonstrated no significant differences between caffeine-treated and control young adult mice in terms of DNA damage index (DI) and frequency. In contrast, when comparing young adult with aged animals, significant differences were observed in DNA damage in blood and hippocampal cells. The differences between aged animals (with or without caffeine) consisted of a significant decrease in DNA DI in the group that received caffeine. In the MN test, an increase in frequency of micronucleated polychromatic (PCE) erythrocytes was noted in aged animals that received water compared to young adult mice. In addition, comparing treated with control aged mu...Continue Reading

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Citations

Jul 29, 2020·Mutagenesis·Adriani Paganini DamianiVanessa Moraes de Andrade
Jan 6, 2019·Neurochemical Research·Michelle Lima GarcezCarina Rodrigues Boeck
Jan 27, 2021·Journal of Toxicology and Environmental Health. Part a·Herbert Gonzaga SousaElcilene Alves de Sousa
Jul 1, 2018·Toxicology and Applied Pharmacology·Marina Tuerlinckx Costa-ValleMarcelo Dutra Arbo

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